ReviewAnnals of internal medicine2009
Narrative review: evolving concepts in potassium homeostasis and hypokalemia.
Review in Annals of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Electrolyte abnormalities in cystic fibrosis: systematic review of the literature.Pediatric nephrology (Berlin, Germany) · 2014Pooled it
- The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis.Frontiers in physiology · 2026Review
- Sexual dimorphism inScientific reports · 2025Article
- Article
- Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice.Cardiac failure review · 2024Review
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls.PLoS computational biology · 2022Article
- Potassium homeostasis: sensors, mediators, and targets.Pflugers Archiv : European journal of physiology · 2022Review
- Optimizing Therapies in Heart Failure: The Role of Potassium Binders.Biomedicines · 2022Review
- Review of the Pathophysiologic and Clinical Aspects of Hypokalemia in Children and Young Adults: an Update.Current treatment options in pediatrics · 2022Review
- Rapid development of vasopressin resistance in dietary KAmerican journal of physiology. Renal physiology · 2021Article
- Recent insights into sodium and potassium handling by the aldosterone-sensitive distal nephron: a review of the relevant physiology.Journal of nephrology · 2020Review
- A Deep-Learning Algorithm (ECG12Net) for Detecting Hypokalemia and Hyperkalemia by Electrocardiography: Algorithm Development.JMIR medical informatics · 2020Article
- The Associations of Diuretics and Laxatives Use with Cardiovascular Mortality. An Individual Patient-Data Meta-analysis of Two Large Cohort Studies.Cardiovascular drugs and therapy · 2019Article
- TRPV4 deletion protects against hypokalemia during systemic KAmerican journal of physiology. Renal physiology · 2019Article
- The renal response to potassium stress: integrating past with present.Current opinion in nephrology and hypertension · 2017Review
- Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.Journal of the American Society of Nephrology : JASN · 2017Article
- The renal TRPV4 channel is essential for adaptation to increased dietary potassium.Kidney international · 2017Article
- Noninvasive quantification of blood potassium concentration from ECG in hemodialysis patients.Scientific reports · 2017Article
- Feedback control indirect response models.Journal of pharmacokinetics and pharmacodynamics · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Humans are intermittently exposed to large variations in potassium intake, which range from periods of fasting to ingestion of potassium-rich meals. These fluctuations would abruptly alter plasma potassium concentration if not for rapid mechanisms, primarily in skeletal muscle and the liver, that buffer the changes in plasma potassium concentration by means of transcellular potassium redistribution and feedback control of renal potassium excretion. However, buffers have capacity limits, and even robust feedback control mechanisms require that the perturbation occur before feedback can initiate corrective action. In contrast, feedforward control mechanisms sense the effect of disturbances on the system's homeostasis. This review highlights recent experimental insights into the participation of feedback and feedforward control mechanisms in potassium homeostasis. New data make clear that feedforward homeostatic responses activate when decreased potassium intake is sensed, even when plasma potassium concentration is still within the normal range and before frank hypokalemia ensues, in addition to the classic feedback activation of renal potassium conservation when plasma potassium concentration decreases. Given the clinical importance of dyskalemias in patients, these novel experimental paradigms invite renewed clinical inquiry into this important area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.