ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2022Article
- Schistosomes in the Lung: Immunobiology and Opportunity.Frontiers in immunology · 2021Review
- Helminth Induced Immunoregulation and Novel Therapeutic Avenue of Allergy.Journal of asthma and allergy · 2020Review
- Evasion of Host Immunity During Fasciola hepatica Infection.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease.Mucosal immunology · 2019Article
- First Responders: Innate Immunity to Helminths.Trends in parasitology · 2018Review
- Role of alarmin cytokines and microRNAs in the host-schistosome interaction.F1000Research · 2018Review
- Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses.Frontiers in immunology · 2018Review
- TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.The Journal of experimental medicine · 2017Article
- Type 2 cytokines: mechanisms and therapeutic strategies.Nature reviews. Immunology · 2015Review
- Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.International journal for parasitology · 2015Article
- Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia.Journal of leukocyte biology · 2015Article
- The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity.The World Allergy Organization journal · 2015Article
- Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.Seminars in immunology · 2014Review
- Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders.Frontiers in immunology · 2014Review
- A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis.Annals of the rheumatic diseases · 2013Article
- Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.Nature reviews. Immunology · 2013Review
- The biology of thymic stromal lymphopoietin (TSLP).Advances in pharmacology (San Diego, Calif.) · 2013Review
- TSLP promotes induction of Th2 differentiation but is not necessary during established allergen-induced pulmonary disease.PloS one · 2013Article
- Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Thymic stromal lymphopoietin was recently identified as a master switch for the development of allergen-driven Th2 responses. However, the role of thymic stromal lymphopoietin (TSLP) in the development of helminth-induced Th2 responses is unclear. Here, using TSLPR(-/-) mice, we show that while TSLPR signaling participates in the development of Schistosoma mansoni egg-induced CD4(+) Th2 responses, it plays only a transient role in the development of Th2-dependent pathology in the lung, liver, and intestine. Studies conducted in a pulmonary granuloma model showed that while a reduction in IL-4/IL-13-dependent granulomatous inflammation and tissue eosinophilia was observed in TSLPR(-/-) mice undergoing a primary response, lesion formation was not affected during a secondary granulomatous response, even though IL-5 and IL-13 were modestly reduced in the knockout mice. To evaluate the importance of TSLPR signaling in the development of a chronic Th2-dependent response, TSLPR(-/-) mice were also infected with S. mansoni cercariae. Here, the only significant difference noted in TSLPR(-/-) mice was a modest decrease in liver fibrosis in acutely infected animals. The transient decrease in fibrosis was associated with increased production of the antifibrotic cytokine IFN-gamma and decreased production of the profibrotic cytokine IL-13. Although the altered cytokine response persisted in chronically infected TSLPR(-/-) mice, it failed to reduce granuloma formation or fibrosis, confirming that TSLPR signaling plays a limited role in the development of chronic Th2-dependent pathology. Collectively, these findings suggest that while TSLPR signaling serves a key role in allergen-driven Th2 responses, it exerts minor regulatory activity during this chronic helminth infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.