ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Cutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Role of follicular homing natural killer cells in HIV infection.Current opinion in HIV and AIDS · 2025Review
- NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics?Frontiers in immunology · 2023Review
- Mucosal-homing natural killer cells are associated with aging in persons living with HIV.Cell reports. Medicine · 2022Article
- Article
- Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection.AIDS (London, England) · 2020Article
- NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?Frontiers in cellular and infection microbiology · 2020Review
- A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation.Nature communications · 2019Article
- Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1.PloS one · 2018Article
- Neutralization and beyond: Antibodies and HIV-1 acquisition.Current Topics In Virology · 2018Article
- Redefining Memory: Building the Case for Adaptive NK Cells.Journal of virology · 2017Review
- Article
- Antigen-specific NK cell memory in rhesus macaques.Nature immunology · 2015Article
- Article
- Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication.AIDS research and human retroviruses · 2015Article
- In-utero infection with HIV-1 associated with suppressed lymphoproliferative responses at birth.Clinical and experimental immunology · 2014Article
- Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.AIDS (London, England) · 2014Article
- Enhanced and efficient detection of virus-driven cytokine expression by human NK and T cells.Journal of virological methods · 2014Article
- Higher Expression of Activating Receptors on Cytotoxic NK Cells is Associated with Early Control on HIV-1C Multiplication.Frontiers in immunology · 2014Article
- Article
- Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.Current HIV research · 2013Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Most infants exposed to HIV-1 in utero and at delivery do not acquire infection. We show that mothers and infants who have CD3-negative cells that respond to HIV-1 peptides are substantially less likely to transmit and acquire infection, respectively. The CD3-negative cells, shown to be NK cells, respond with remarkable specificity and high magnitude to HIV-1 peptides from Env (envelope) and Reg (regulatory) protein regions, as measured by a whole blood intracellular cytokine assay only in the context of HIV-1 infection or exposure. These findings identify an important new measure of protective immunity to HIV-1 that highlights the importance of innate immunity in preventing the establishment of HIV-1 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.