ArticleThe Journal of cell biology2009
Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026Review
- Uip4p modulates nuclear pore complex function inNucleus (Austin, Tex.) · 2022Article
- Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex.Cell research · 2022Article
- Identification and localization of Nup170 in the microsporidian Nosema bombycis.Parasitology research · 2021Article
- Article
- A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits.Nature communications · 2018Article
- Possible Molecular Markers for the Diagnosis of Pancreatic Ductal Adenocarcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The nuclear pore complex--structure and function at a glance.Journal of cell science · 2015Review
- Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin.Nucleus (Austin, Tex.) · 2015Article
- Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex.Structure (London, England : 1993) · 2013Article
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Lumenal interactions in nuclear pore complex assembly and stability.Molecular biology of the cell · 2011Article
- Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly.Molecular biology of the cell · 2011Article
- Changes in the nuclear envelope environment affect spindle pole body duplication in Saccharomyces cerevisiae.Genetics · 2010Article
- Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane.The Journal of cell biology · 2010Article
- Nuclear pore biogenesis into an intact nuclear envelope.Chromosoma · 2010Review
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution.The Journal of cell biology · 2010Article
- Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization.Molecular biology of the cell · 2010Article
- Nuclear pore complexes: guardians of the nuclear genome.Cold Spring Harbor symposia on quantitative biology · 2010Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How individual nucleoporins (Nups) perform their role in nuclear pore structure and function is largely unknown. In this study, we examined the structure of purified Nup170 to obtain clues about its function. We show that Nup170 adopts a crescent moon shape with two structurally distinct and separable domains, a beta-propeller N terminus and an alpha-solenoid C terminus. To address the individual roles of each domain, we expressed these domains separately in yeast. Notably, overexpression of the Nup170 C domain was toxic in nup170Delta cells and caused accumulation of several Nups in cytoplasmic foci. Further experiments indicated that the C-terminal domain anchors Nup170 to nuclear pores, whereas the N-terminal domain functions to recruit or retain a subset of Nups, including Nup159, Nup188, and Pom34, at nuclear pores. We conclude that Nup170 performs its role as a structural adapter between cytoplasmically oriented Nups and the nuclear pore membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.