ArticleGenetics2009
Quantitative trait loci for aggressive behavior in Drosophila melanogaster.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta).PloS one · 2023Article
- Epistasis for head morphology in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- A genetic screen for Drosophila social isolation mutants and analysis of sex pistol.Scientific reports · 2021Article
- Ecotype differences in aggression, neural activity and behaviorally relevant gene expression in cichlid fish.Genes, brain, and behavior · 2020Article
- Association between molecular markers and behavioral phenotypes in the immatures of a butterfly.Genetics and molecular biology · 2018Article
- Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information.Scientific reports · 2017Article
- Genetic architecture of natural variation in visual senescence in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.PLoS genetics · 2016Article
- Integrating molecular mechanisms into quantitative genetics to understand consistent individual differences in behavior.Current opinion in behavioral sciences · 2015Article
- Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee.Genome biology · 2015Article
- Mendelizing all Components of a Pyramid of Three Yield QTL in Tomato.Frontiers in plant science · 2015Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Epistasis and quantitative traits: using model organisms to study gene-gene interactions.Nature reviews. Genetics · 2014Review
- Linkage relationships among multiple QTL for horticultural traits and late blight (P. infestans) resistance on chromosome 5 introgressed from wild tomato Solanum habrochaites.G3 (Bethesda, Md.) · 2013Article
- Effects of single and combined genotypes of MC4R and POU1F1 genes on two production traits in Langshan chicken.Molecular biology reports · 2013Article
- The causes of variation in learning and behavior: why individual differences matter.Frontiers in psychology · 2013Article
- Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster.Genetics research · 2012Article
- Evolution of multiple additive loci caused divergence between Drosophila yakuba and D. santomea in wing rowing during male courtship.PloS one · 2012Article
- Genetic contributions to behavioural diversity at the gene-environment interface.Nature reviews. Genetics · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aggressive behavior is observed across animal taxa and is likely to be evolutionarily conserved. Although potentially advantageous, aggression can have social and health consequences in humans, and is a component of a number of psychiatric disorders. As a complex genetic trait, it is modulated by numerous quantitative trait loci (QTL) with allelic effects that can vary in direction and magnitude and that are sensitive to environmental perturbations. Assays to quantify aggressive behavior in Drosophila melanogaster have been developed, making this an ideal model system in which to dissect the genomic architecture underlying manifestation of and variation in aggressive behavior. Here, we map QTL affecting variation in aggression between two wild-type Drosophila strains. We identified a minimum of five QTL in a genomewide scan: two on chromosome 2 and three on chromosome 3. At least three and possibly all five of these QTL interact epistatically. We used deficiency complementation mapping to subdivide two linked, epistatically interacting QTL of large effect on chromosome 3 into at least six QTL, and complementation tests to mutations identified four candidate quantitative trait genes. Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.