ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Familial aggregation of survival and late female reproduction.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Slowing down the clock on ovarian aging-does the ovary hold the secret to the fountain of youth?GeroScience · 2026Review
- Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespan.medRxiv : the preprint server for health sciences · 2025Article
- The evolution of aging and lifespan.Trends in genetics : TIG · 2023Review
- DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.The Journal of clinical endocrinology and metabolism · 2023Observational
- Unraveling female reproductive senescence to enhance healthy longevity.Cell research · 2023Review
- Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency.The Journal of clinical endocrinology and metabolism · 2022Observational
- Article
- Germline mutation rates in young adults predict longevity and reproductive lifespan.Scientific reports · 2020Article
- The Long Harm of Childhood: Childhood Exposure to Mortality and Subsequent Risk of Adult Mortality in Utah and The Netherlands.European journal of population = Revue europeenne de demographie · 2019Article
- Reproductive History and Later-Life Comorbidity Trajectories: A Medicare-Linked Cohort Study From the Utah Population Database.Demography · 2015Article
- The Trade-Off between Female Fertility and Longevity during the Epidemiological Transition in the Netherlands.PloS one · 2015Article
- Reproductive history and chronic hepatic steatosis in the Michigan Study of Women's Health Across the Nation.Journal of women's health (2002) · 2015Article
- Extended maternal age at birth of last child and women's longevity in the Long Life Family Study.Menopause (New York, N.Y.) · 2015Article
- Determinants of exceptional human longevity: new ideas and findings.Vienna yearbook of population research · 2013Article
- The epidemiology of longevity and exceptional survival.Epidemiologic reviews · 2013Review
- Telomeres and human reproduction.Fertility and sterility · 2013Review
- Within- and between-species study of extreme longevity--comments, commonalities, and goals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Perinatal Risks in "Late Motherhood" Defined Based On Parity and Preterm Birth Rate - an Analysis of the German Perinatal Survey (20th Communication).Geburtshilfe und Frauenheilkunde · 2012Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Women giving birth at advanced reproductive ages in natural fertility conditions have been shown to have superior postmenopausal longevity. It is unknown whether improved survival is more likely among relatives of late-fertile women. This study compares survival past age 50 of men with and without a late-fertile sister in two populations: Utahns born in 1800-1869 identified from the Utah Population Database and Québec residents born in 1670-1750 identified from the Programme de recherche en démographie historique. Male survival was greater for those with, rather than without, a sister reproducing after age 45, particularly among men with at least three sisters (Utah rate ratio [RR] = .801, 95% CI = 0.687-0.940; Quebec RR = .786, 95% CI = 0.664-0.931). Survival of wives was unaffected by whether their husbands had a late-fertile sister, suggesting a weak influence of unmeasured socioenvironmental factors. These results support the hypothesis that late female fertility and slow somatic aging may be promoted by the same genetic variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.