SynthesisHuman molecular genetics2009
The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
Synthesis in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia.Genes, brain, and behavior · 2012Pooled it
- PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.Journal of molecular neuroscience : MN · 2012Pooled it
- Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Molecular psychiatry · 2012Pooled it
- A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men.The Prostate · 2013Trial
- Cognitive Deficits in Schizophrenia: Brain Deorganization and Neurorehabilitation.Advances in experimental medicine and biology · 2026Review
- Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders.The Journal of cell biology · 2024Review
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- Connecting the Neurobiology of Developmental Brain Injury: Neuronal Arborisation as a Regulator of Dysfunction and Potential Therapeutic Target.International journal of molecular sciences · 2021Review
- Dosage effects of human ribosomal genes (rDNA) in health and disease.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Review
- The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.Human molecular genetics · 2018Article
- Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.Molecular psychiatry · 2018Article
- Mild prominence of the Sylvian fissure in a Bainbridge-Ropers syndrome patient with a novel frameshift variant inClinical case reports · 2018Article
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia.Behavioral and brain functions : BBF · 2015Article
- Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.Current molecular medicine · 2015Review
- Disrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia.Psychiatry investigation · 2015Article
- Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population.Cell stress & chaperones · 2014Article
- Wnts in adult brain: from synaptic plasticity to cognitive deficiencies.Frontiers in cellular neuroscience · 2013Review
- Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.Journal of neurochemistry · 2013Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
Abstract
Association studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia. DISC1 encodes a multifunctional scaffold protein involved in neurodevelopmental processes implicated in the etiology of schizophrenia. The present study explores the contribution of the DISC locus to schizophrenia using three different approaches: (i) systematic association mapping aimed at detecting DISC risk variants in a schizophrenia sample from a central European population (556 SNPs, n = 1621 individuals). In this homogenous sample, a circumscribed DISC1 interval in intron 9 was significantly associated with schizophrenia in females (P = 4 x 10(-5)) and contributed most strongly to early-onset cases (P = 9 x 10(-5)). The odds ratios (ORs) were in the range of 1.46-1.88. (ii) The same sample was used to test for the locus-specific SNP-SNP interaction most recently associated with schizophrenia. Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57). (iii) In order to detect additional schizophrenia variants, a meta-analysis was performed using nine schizophrenia samples from different European populations (50 SNPs, n = 10 064 individuals maximum, n = 3694 minimum). We found evidence for a common schizophrenia risk interval within DISC1 intron 4-6 (P = 0.002, OR 1.27). The findings point to a complex association between schizophrenia and DISC, including the presence of different risk loci and SNP interplay effects. Furthermore, our phenotype-genotype results--including the consideration of sex-specific effects--highlight the value of homogenous samples in mapping risk genes for schizophrenia in general, and at the DISC locus in particular.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.