ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2009
MHC standing genetic variation and pathogen resistance in wild Atlantic salmon.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Pooled it
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- Insights from a chum salmon (Oncorhynchus keta) genome assembly regarding whole-genome duplication and nucleotide variation influencing gene function.G3 (Bethesda, Md.) · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
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- Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics.Molecular ecology · 2022Article
- Does genetic diversity protect host populations from parasites? A meta-analysis across natural and agricultural systems.Evolution letters · 2021Article
- The pink salmon genome: Uncovering the genomic consequences of a two-year life cycle.PloS one · 2021Article
- Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance toGenes · 2020Article
- Specific pathogens and microbial abundance within liver and kidney tissues of wild marine fish from the Eastern Mediterranean Sea.Microbial biotechnology · 2020Article
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- Divergent Allele Advantage Provides a Quantitative Model for Maintaining Alleles with a Wide Range of Intrinsic Merits.Genetics · 2019Article
- Small-scale intraspecific patterns of adaptive immunogenetic polymorphisms and neutral variation in Lake Superior lake trout.Immunogenetics · 2018Article
- Range-wide parallel climate-associated genomic clines in Atlantic salmon.Royal Society open science · 2017Article
- Drift, selection, or migration? Processes affecting genetic differentiation and variation along a latitudinal gradient in an amphibian.BMC evolutionary biology · 2017Article
- Cheetahs have a stronger constitutive innate immunity than leopards.Scientific reports · 2017Article
- Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens are increasingly emerging in human-altered environments as a serious threat to biodiversity. In this context of rapid environmental changes, improving our knowledge on the interaction between ecology and evolution is critical. The objective of this study was to evaluate the influence of an immunocompetence gene, the major histocompatibility complex (MHC) class IIbeta, on the pathogen infection levels in wild Atlantic salmon populations, Salmo salar, and identify selective agents involved in contemporary coevolution. MHC variability and bacterial infection rate were determined throughout the summer in juvenile salmon from six rivers belonging to different genetic and ecological regions in Québec, Canada. A total of 13 different pathogens were identified in kidney by DNA sequence analysis, including a predominant myxozoa, most probably recently introduced in North America. Infection rates were the highest in southern rivers at the beginning of the summer (average 47.6+/-6.3% infected fish). One MHC allele conferred a 2.9 times greater chance of being resistant to myxozoa, while another allele increased susceptibility by 3.4 times. The decrease in frequency of the susceptibility allele but not other MHC or microsatellite alleles during summer was suggestive of a mortality event from myxozoa infection. These results supported the hypothesis of pathogen-driven selection in the wild by means of frequency-dependent selection or change in selection through time and space rather than heterozygous advantage, and underline the importance of MHC standing genetic variation for facing pathogens in a changing environment.
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