ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2009
Generation of histo-anatomically representative models of the individual heart: tools and application.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Technologies, Clinical Applications, and Implementation Barriers of Digital Twins in Precision Cardiology: Systematic Review.JMIR cardio · 2026Pooled it
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways.Frontiers in physics · 2023Article
- Cardiac biophysical detailed synergetic modality rendering and visible correlation.Frontiers in physiology · 2023Article
- Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering.Micromachines · 2021Review
- An Inverse Eikonal Method for Identifying Ventricular Activation Sequences from Epicardial Activation Maps.Journal of computational physics · 2020Article
- An Introductory Overview of Image-Based Computational Modeling in Personalized Cardiovascular Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations.PloS one · 2020Article
- Cardiovascular disease models: A game changing paradigm in drug discovery and screening.Biomaterials · 2019Review
- Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology.Frontiers in physiology · 2018Review
- Trabecular Architecture Determines Impulse Propagation Through the Early Embryonic Mouse Heart.Frontiers in physiology · 2018Article
- Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks.Chaos (Woodbury, N.Y.) · 2017Article
- Improved identifiability of myocardial material parameters by an energy-based cost function.Biomechanics and modeling in mechanobiology · 2017Article
- Transformation diffusion reconstruction of three-dimensional histology volumes from two-dimensional image stacks.Medical image analysis · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016Article
- Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging.Scientific reports · 2016Article
- Mapping cardiac microstructure of rabbit heart in different mechanical states by high resolution diffusion tensor imaging: A proof-of-principle study.Progress in biophysics and molecular biology · 2016Article
- Multiphysics and multiscale modelling, data-model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics.Interface focus · 2016Review
- Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation.Journal of computational physics · 2016Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
This paper presents methods to build histo-anatomically detailed individualized cardiac models. The models are based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and are used to investigate individualized cardiac function. The current state of the art is reviewed, and its limitations are discussed. We assess the challenges associated with the generation of histo-anatomically representative individualized in silico models of the heart. The entire processing pipeline including image acquisition, image processing, mesh generation, model set-up and execution of computer simulations, and the underlying methods are described. The multifaceted challenges associated with these goals are highlighted, suitable solutions are proposed, and an important application of developed high-resolution structure-function models in elucidating the effect of individual structural heterogeneity upon wavefront dynamics is demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.