ArticleIn vivo (Athens, Greece)
The columnar-lined mucosa in the distal esophagus. A preliminary study in baboons.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- The length of the Barrett's mucosa in baboons, revisited.Anticancer research · 2012Article
- Mucous gland metaplasia in the esophagus and gastric mucosa in baboons.Anticancer research · 2011Article
- Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin.Anticancer research · 2010Article
- Further studies on the frequency and length of the glandulo-metaplastic esophageal mucosa in baboons.In vivo (Athens, Greece)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFor anatomists, the cardia is a portion of the stomach. However, at the histological level, the cardiac mucosa, described as columnar-lined with mucus-producing glands (CLMMG), is for some pathologists part of the stomach (already present at birth) and for others a metaplastic change of the esophagus induced by gastroesophageal reflux (GER). MATERIALS AND
methodsThe distal esophagus and the proximal stomach of 5 adult male baboons were removed en bloc at autopsy. The distance between the most distal part of the squamous epithelium of the esophagus and the first oxyntic fundic gastric gland (representing the entire CLMMG) was assessed using an ocular microscale.
resultsThe length of the CLMMG varied from 1.2 mm to 12.4 mm. The CLMMG had replaced the squamous epithelium of the distal esophagus in all 5 baboons. DISCUSSION: Regurgitation with rumination is a natural physiological, daily, recurrent process in baboons that leads to GER. The luminal cytoplasmic vacuoles with neutral mucins contained in the columnar cells and the neutral mucins produced by the mucin glands buffer the low pH of the gastric juices that reflux into the distal esophagus. This protective action against the acid refluxate cannot be achieved by the squamous epithelium.
conclusionThe results of this preliminary investigation suggest that in baboons, CLMMG is an adaptation process of the esophageal mucosal to the low pH microenvironment conveyed by protracted GER.
Indexed as
Identifiers
19414413PMC3479648W2131424477What OpenQuestion holds
Registered trials
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