ArticleJournal of molecular biology2009
Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.
Article in Journal of molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Golgi vesicle tether p115 can bind directly to the ER exit site organiser Sec16A.Journal of cell science · 2026Article
- Motor Function of the Two-Component EEA1-Rab5 Revealed by dcFCCS.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- AtypicalScience advances · 2022Article
- The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases.Frontiers in cell and developmental biology · 2020Review
- Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.The Journal of biological chemistry · 2015Article
- p115-SNARE interactions: a dynamic cycle of p115 binding monomeric SNARE motifs and releasing assembled bundles.Traffic (Copenhagen, Denmark) · 2015Article
- P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.World journal of gastroenterology · 2013Article
- The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi.Cold Spring Harbor perspectives in biology · 2013Review
- Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat.Cellular logistics · 2013Article
- Functional and genomic analyses of alpha-solenoid proteins.PloS one · 2013Article
- Retrograde vesicle transport in the Golgi.Protoplasma · 2012Review
- The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.Nature communications · 2012Article
- Identification of a functional domain within the p115 tethering factor that is required for Golgi ribbon assembly and membrane trafficking.Journal of cell science · 2012Article
- Structure of Golgi transport proteins.Cold Spring Harbor perspectives in biology · 2011Review
- Entry and exit mechanisms at the cis-face of the Golgi complex.Cold Spring Harbor perspectives in biology · 2011Review
- The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.The Journal of biological chemistry · 2011Article
- The golgin coiled-coil proteins of the Golgi apparatus.Cold Spring Harbor perspectives in biology · 2011Review
- Role of Rab GTPases in membrane traffic and cell physiology.Physiological reviews · 2011Review
- Armadillo motifs involved in vesicular transport.PloS one · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Molecular tethers have a central role in the organization of the complex membrane architecture of eukaryotic cells. p115 is a ubiquitous, essential tether involved in vesicle transport and the structural organization of the exocytic pathway. We describe two crystal structures of the N-terminal domain of p115 at 2.0 A resolution. The p115 structures show a novel alpha-solenoid architecture constructed of 12 armadillo-like, tether-repeat, alpha-helical tripod motifs. We find that the H1 TR binds the Rab1 GTPase involved in endoplasmic reticulum to Golgi transport. Mutation of the H1 motif results in the dominant negative inhibition of endoplasmic reticulum to Golgi trafficking. We propose that the H1 helical tripod contributes to the assembly of Rab-dependent complexes responsible for the tether and SNARE-dependent fusion of membranes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.