ArticleBiophysical journal2009
Nucleation and growth of integrin adhesions.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit.Biomechanics and modeling in mechanobiology · 2024Article
- Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit.bioRxiv : the preprint server for biology · 2023Article
- Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force.Current biology : CB · 2020Article
- Modeling membrane nanotube morphology: the role of heterogeneity in composition and material properties.Scientific reports · 2020Article
- Equilibrium Modeling of the Mechanics and Structure of the Cancer Glycocalyx.Biophysical journal · 2019Article
- High expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors.Bioorganic & medicinal chemistry · 2018Article
- Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.Biophysical journal · 2018Article
- Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM).Light, science & applications · 2018Article
- Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues.Current opinion in chemical biology · 2017Review
- Binding equilibrium and kinetics of membrane-anchored receptors and ligands in cell adhesion: Insights from computational model systems and theory.Cell adhesion & migration · 2016Review
- Tracking surface glycans on live cancer cells with single-molecule sensitivity.Angewandte Chemie (International ed. in English) · 2015Article
- Structural and mechanical functions of integrins.Biophysical reviews · 2014Review
- The role of mechanics in actin stress fiber kinetics.Experimental cell research · 2013Review
- Syndecan and integrin interactomes: large complexes in small spaces.Current opinion in structural biology · 2012Review
- Biomimetic emulsions reveal the effect of mechanical forces on cell-cell adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Reflectivity and topography of cells grown on glass-coverslips measured with phase-shifted laser feedback interference microscopy.Biomedical optics express · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present a model that provides a mechanistic understanding of the processes that govern the formation of the earliest integrin adhesions ex novo from an approximately planar plasma membrane. Using an analytic analysis of the free energy of a dynamically deformable membrane containing freely diffusing receptors molecules and long repeller molecules that inhibit integrins from binding with ligands on the extracellular matrix, we predict that a coalescence of polymerizing actin filaments can deform the membrane toward the extracellular matrix and facilitate integrin binding. Monte Carlo simulations of this system show that thermally induced membrane fluctuations can either zip-up and increase the radius of a nucleated adhesion or unzip and shrink an adhesion, but the fluctuations cannot bend the ventral membrane to nucleate an adhesion. To distinguish this integrin adhesion from more mature adhesions, we refer to this early adhesion as a nouveau adhesion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.