ArticleThe New phytologist2009
A functional analysis of the pyrimidine catabolic pathway in Arabidopsis.
Article in The New phytologist, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 90 citations in OpenAlex.
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- Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases.Plant direct · 2024Article
- The serine-glycine-one-carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development.The Plant cell · 2024Article
- Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA.Nucleic acids research · 2023Article
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond.Journal of experimental botany · 2023Article
- Metabolomic and Transcriptomic Changes Underlying the Effects ofAnimals : an open access journal from MDPI · 2023Article
- Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings.Frontiers in plant science · 2023Article
- New Insights into rice pyrimidine catabolic enzymes.Frontiers in plant science · 2023Article
- Identification of fungal dihydrouracil-oxidase genes by expression in Saccharomyces cerevisiae.Antonie van Leeuwenhoek · 2022Article
- Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes.Nature chemistry · 2022Article
- Molecular mechanisms of resistance toFrontiers in plant science · 2022Article
- The Eucalyptus grandis chloroplast proteome: Seasonal variations in leaf development.PloS one · 2022Article
- Structure Characterization ofFrontiers in microbiology · 2022Article
- Advances in biotechnological production of β-alanine.World journal of microbiology & biotechnology · 2021Review
- Multi-scale comparative transcriptome analysis reveals key genes and metabolic reprogramming processes associated with oil palm fruit abscission.BMC plant biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
* Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is degraded to beta-alanine, CO(2) and NH(3) through sequential activities of dihydropyrimidine dehydrogenase (EC 1.3.1.2, PYD1), dihydropyrimidinase (EC 3.5.2.2, PYD2) and beta-ureidopropionase (EC 3.5.1.6, PYD3). * A proposed function of this pathway, in addition to the maintenance of pyrimidine homeostasis, is the recycling of pyrimidine nitrogen to general nitrogen metabolism. PYD expression and catabolism of [2-(14)C]-uracil are markedly elevated in response to nitrogen limitation in plants, which can utilize uracil as a nitrogen source. * PYD1, PYD2 and PYD3 knockout mutants were used for functional analysis of this pathway in Arabidopsis. pyd mutants exhibited no obvious phenotype under optimal growing conditions. pyd2 and pyd3 mutants were unable to catabolize [2-(14)C]-uracil or to grow on uracil as the sole nitrogen source. By contrast, catabolism of uracil was reduced by only 40% in pyd1 mutants, and pyd1 seedlings grew nearly as well as wild-type seedlings with a uracil nitrogen source. These results confirm PYD1 function and suggest the possible existence of another, as yet unknown, activity for uracil degradation to dihydrouracil in this plant. * The localization of PYD-green fluorescent protein fusions in the plastid (PYD1), secretory system (PYD2) and cytosol (PYD3) suggests potentially complex metabolic regulation.
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