ReviewVirchows Archiv : an international journal of pathology2010
Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers.
Review in Virchows Archiv : an international journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Sarcomas with EWSR1::Non-ETS Fusion (EWSR1::NFATC2 and EWSR1::PATZ1).Surgical pathology clinics · 2024Review
- Molecular pathways and therapeutic strategies in dermatofibrosarcoma protuberans (DFSP): unravelling the tumor's genetic landscape.EXCLI journal · 2024Review
- Extensive analysis of 59 sarcoma-related fusion genes identified pazopanib as a potential inhibitor to COL1A1-PDGFB fusion gene.Cancer science · 2023Article
- Undifferentiated pleomorphic sarcoma of the extremity and trunk: a retrospective cohort study of 166 cases in a large institution.Translational cancer research · 2022Article
- Proteomic profiling of soft tissue sarcomas with SWATH mass spectrometry.Journal of proteomics · 2021Article
- Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes.Molecular cancer research : MCR · 2020Article
- New fusion sarcomas: histopathology and clinical significance of selected entities.Human pathology · 2019Review
- Co-expression Network Analysis Identifies Four Hub Genes Associated With Prognosis in Soft Tissue Sarcoma.Frontiers in genetics · 2019Article
- iGC-an integrated analysis package of gene expression and copy number alteration.BMC bioinformatics · 2017Article
- FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro.Oncotarget · 2015Article
- Article
- Desktop transcriptome sequencing from archival tissue to identify clinically relevant translocations.The American journal of surgical pathology · 2013Article
- A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.Expert opinion on therapeutic targets · 2013Review
- A 63-year-old woman presenting with a synovial sarcoma of the hand: a case report.Journal of medical case reports · 2012Article
- Sarcoma spreads primarily through the vascular system: are there biomarkers associated with vascular spread?Clinical & experimental metastasis · 2012Article
- ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour.The Journal of pathology · 2012Article
- A review of controversies in the management of soft tissue sarcomas.The Indian journal of surgery · 2012Article
- The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas.Journal of translational medicine · 2011Article
- A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients.BMC cancer · 2011Article
- Biphasic synovial sarcoma of the extremity: quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation.Case reports in oncology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Soft tissue sarcomas are malignant neoplasms derived from mesenchymal tissues. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. In the past decade, gene expression profiling has been applied to sarcomas to facilitate understanding of sarcoma pathogenesis and to identify diagnostic, prognostic, and predictive markers. In this paper, we review this body of work and discuss how gene expression profiling has led to advancements in the understanding of sarcoma pathobiology, the identification of clinically useful biomarkers, and the refinement of sarcoma classification schemes. Lastly, we conclude with a discussion of strategies to further optimize the translation of gene expression data into a greater understanding of sarcoma pathogenesis and improved clinical outcomes for sarcoma patients.
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