ArticlePloS one2009
IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pooled it
- IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.Yonsei medical journal · 2015Pooled it
- The association of interleukin-10 -1082, -819, -592 polymorphisms and tuberculosis risk.Saudi medical journal · 2015Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.PloS one · 2015Pooled it
- Association between IL-10 gene polymorphisms and susceptibility of tuberculosis: evidence based on a meta-analysis.PloS one · 2014Pooled it
- Trial
- Genetic epidemiology of resistance to M. tuberculosis Infection: importance of study design and recent findings.Genes and immunity · 2023Review
- Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Advances in the understanding of Mycobacterium tuberculosis transmission in HIV-endemic settings.The Lancet. Infectious diseases · 2019Review
- The Interplay of Human andFrontiers in genetics · 2019Review
- Infection resisters: targets of new research for uncovering natural protective immunity againstF1000Research · 2019Review
- The Research Progress of Host Genes and Tuberculosis Susceptibility.Oxidative medicine and cellular longevity · 2019Review
- Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection.Nature reviews. Immunology · 2018Review
- Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives.The Lancet. Infectious diseases · 2018Review
- Factors influencing the higher incidence of tuberculosis among migrants and ethnic minorities in the UK.F1000Research · 2018Review
- Early clearance versus control: what is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure toF1000Research · 2018Review
- Genetic Resistance toFrontiers in immunology · 2018Review
- Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows.BMC genomics · 2017Article
- Mycobacterial Dormancy Systems and Host Responses in Tuberculosis.Frontiers in immunology · 2017Review
- CD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin.PloS one · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence from genetic association and twin studies indicates that susceptibility to tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that encoding interleukin-10 (IL10). In a group of 2010 Ghanaian patients with pulmonary TB and 2346 healthy controls exposed to Mycobacterium tuberculosis, among them 129 individuals lacking a tuberculin skin test (PPD) response, we genotyped four IL10 promoter variants at positions -2849 , -1082 , -819 , and -592 and reconstructed the haplotypes. The IL10 low-producer haplotype -2849A/-1082A/-819C/-592C, compared to the high-producer haplotype -2849G/-1082G/-819C/-592C, occurred less frequent among PPD-negative controls than among cases (OR 2.15, CI 1.3-3.6) and PPD-positive controls (OR 2.09, CI 1.2-3.5). Lower IL-10 plasma levels in homozygous -2849A/-1082A/-819C/-592C carriers, compared to homozygous -2849G/-1082G/-819C/-592C carriers, were confirmed by a IL-10 ELISA (p = 0.016). Although we did not observe differences between the TB patients and all controls, our results provide evidence that a group of individuals exposed to M. tuberculosis transmission is genetically distinct from healthy PPD positives and TB cases. In these PPD-negative individuals, higher IL-10 production appears to reflect IL-10-dependent suppression of adaptive immune responses and sustained long-term specific anergy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.