ReviewNature reviews. Rheumatology2009
Gene-expression profiling in rheumatic disease: tools and therapeutic potential.
Review in Nature reviews. Rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Unique gene expression profile in osteoarthritis synovium compared with cartilage: analysis of publicly accessible microarray datasets.Rheumatology international · 2016Pooled it
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- Development and validation of novel inflammatory response-related gene signature for sepsis prognosis.Journal of Zhejiang University. Science. B · 2022Article
- Association of genetic variation of the six gene prognostic model for castration-resistant prostate cancer with survival.The Prostate · 2019Article
- Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method.Molecular medicine reports · 2018Article
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- Microarray analysis after adipose derived mesenchymal stem cells injection in monosodium iodoacetate-induced osteoarthritis rats.Genes & genomics · 2018Article
- Gene expression profiles of peripheral blood mononuclear cells in primary biliary cirrhosis.Clinical and experimental medicine · 2014Article
- Gene expression analysis in RA: towards personalized medicine.The pharmacogenomics journal · 2014Review
- Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside.Pediatric rheumatology online journal · 2014Review
- From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine.Journal of data mining in genomics & proteomics · 2012Article
- LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood.BMC clinical pathology · 2011Article
- Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis.Arthritis and rheumatism · 2010Article
- A genomic approach to human autoimmune diseases.Annual review of immunology · 2010Review
- Pharmacogenomic discovery using cell-based models.Pharmacological reviews · 2009Review
- HDAC inhibition in lupus models.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene-expression profiling is a powerful tool for the discovery of molecular fingerprints that underlie human disease. Microarray technologies allow the analysis of messenger RNA transcript levels for every gene in the genome. However, gene-expression profiling is best viewed as part of a pipeline that extends from sample collection through clinical application. Key genes and pathways identified by microarray profiling should be validated in independent sample sets and with alternative technologies. Analysis of relevant signaling pathways at the protein level is an important step towards understanding the functional consequences of aberrant gene expression. Peripheral blood is a convenient and rich source of potential biomarkers, but surveying purified cell populations and target tissues can also enhance our understanding of disease states. In rheumatic disease, probing the transcriptome of circulating immune cells has shed light on mechanisms underlying the pathogenesis of complex diseases, such as systemic lupus erythematosus. As these discoveries advance through the pipeline, a variety of clinical applications are on the horizon, including the use of molecular fingerprints to aid in diagnosis and prognosis, improved use of existing therapies, and the development of drugs that target relevant genes and pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.