ArticleGenome research2009
Fine-scaled human genetic structure revealed by SNP microarrays.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
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- Population Stratification and Underrepresentation of Indian Subcontinent Genetic Diversity in the 1000 Genomes Project Dataset.Genome biology and evolution · 2016Article
- Coevolution of genes and languages and high levels of population structure among the highland populations of Daghestan.Journal of human genetics · 2016Article
- Fast individual ancestry inference from DNA sequence data leveraging allele frequencies for multiple populations.BMC bioinformatics · 2015Article
- Early modern human dispersal from Africa: genomic evidence for multiple waves of migration.Investigative genetics · 2015Article
- A genetic mechanism for Tibetan high-altitude adaptation.Nature genetics · 2014Article
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- Mobile element scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations.Genome research · 2013Article
- The GenoChip: a new tool for genetic anthropology.Genome biology and evolution · 2013Article
- Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians.PLoS genetics · 2013Article
- Genome-wide scan with nearly 700,000 SNPs in two Sardinian sub-populations suggests some regions as candidate targets for positive selection.European journal of human genetics : EJHG · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 5 countries.
Funding
Abstract
We report an analysis of more than 240,000 loci genotyped using the Affymetrix SNP microarray in 554 individuals from 27 worldwide populations in Africa, Asia, and Europe. To provide a more extensive and complete sampling of human genetic variation, we have included caste and tribal samples from two states in South India, Daghestanis from eastern Europe, and the Iban from Malaysia. Consistent with observations made by Charles Darwin, our results highlight shared variation among human populations and demonstrate that much genetic variation is geographically continuous. At the same time, principal components analyses reveal discernible genetic differentiation among almost all identified populations in our sample, and in most cases, individuals can be clearly assigned to defined populations on the basis of SNP genotypes. All individuals are accurately classified into continental groups using a model-based clustering algorithm, but between closely related populations, genetic and self-classifications conflict for some individuals. The 250K data permitted high-level resolution of genetic variation among Indian caste and tribal populations and between highland and lowland Daghestani populations. In particular, upper-caste individuals from Tamil Nadu and Andhra Pradesh form one defined group, lower-caste individuals from these two states form another, and the tribal Irula samples form a third. Our results emphasize the correlation of genetic and geographic distances and highlight other elements, including social factors that have contributed to population structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.