ArticleGenome research2009
Evolutionary descent of a human chromosome 6 neocentromere: a jump back to 17 million years ago.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Unconventional centromere architectures in Tapirus indicus reveal hotspots for satellite-free centromere formation in Perissodactyla.Communications biology · 2026Article
- A segmental duplication-mediated deletion leads to neocentromere formation in orangutans.bioRxiv : the preprint server for biology · 2026Article
- Pan-centromere reveals widespread centromere repositioning of soybean genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Robertsonian Fusion and Centromere Repositioning Contributed to the Formation of Satellite-free Centromeres During the Evolution of Zebras.Molecular biology and evolution · 2022Article
- Alpha Satellite Insertion Close to an Ancestral Centromeric Region.Molecular biology and evolution · 2021Article
- Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects.International journal of genomics · 2021Article
- Article
- Birth, evolution, and transmission of satellite-free mammalian centromeric domains.Genome research · 2018Article
- Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation.Scientific reports · 2018Article
- Recurrent establishment of de novo centromeres in the pericentromeric region of maize chromosome 3.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- Epigenetic origin of evolutionary novel centromeres.Scientific reports · 2017Article
- Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome.PLoS genetics · 2016Article
- The evolutionary life cycle of the resilient centromere.Chromosoma · 2012Review
- Neocentromeres and epigenetically inherited features of centromeres.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Flexibility of centromere and kinetochore structures.Trends in genetics : TIG · 2012Review
- Putative CENP-B paralogues are not present at mammalian centromeres.Chromosoma · 2012Article
- Centromere repositioning in mammals.Heredity · 2012Review
- Formation of novel CENP-A domains on tandem repetitive DNA and across chromosome breakpoints on human chromosome 8q21 neocentromeres.Chromosoma · 2011Article
- High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular cytogenetics provides a visual, pictorial record of the tree of life, and in this respect the fusion origin of human chromosome 2 is a well-known paradigmatic example. Here we report on a variant chromosome 6 in which the centromere jumped to 6p22.1. ChIP-chip experiments with antibodies against the centromeric proteins CENP-A and CENP-C exactly defined the neocentromere as lying at chr6:26,407-26,491 kb. We investigated in detail the evolutionary history of chromosome 6 in primates and found that the primate ancestor had a homologous chromosome with the same marker order, but with the centromere located at 6p22.1. Sometime between 17 and 23 million years ago (Mya), in the common ancestor of humans and apes, the centromere of chromosome 6 moved from 6p22.1 to its current location. The neocentromere we discovered, consequently, has jumped back to the ancestral position, where a latent centromere-forming potentiality persisted for at least 17 Myr. Because all living organisms form a tree of life, as first conceived by Darwin, evolutionary perspectives can provide compelling underlying explicative grounds for contemporary genomic phenomena.
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