ArticleThe Journal of bone and joint surgery. American volume2009
Evidence for an inherited predisposition contributing to the risk for rotator cuff disease.
Article in The Journal of bone and joint surgery. American volume, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Genetic basis of rotator cuff injury: a systematic review.BMC medical genetics · 2019Pooled it
- Genetic and familial predisposition to rotator cuff disease: a systematic review.Journal of shoulder and elbow surgery · 2017Pooled it
- Specific exercises for subacromial pain.Acta orthopaedica · 2017Trial
- Shoulder and genetics: what orthopedic surgeons need to know.JSES reviews, reports, and techniques · 2026Review
- Rotator cuff surgery and semantics : definitions matter.Bone & joint open · 2025Article
- Standardizing phenotypic algorithms for the classification of degenerative rotator cuff tear from electronic health record systems.JAMIA open · 2025Article
- The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair.Gels (Basel, Switzerland) · 2024Review
- Identification of rare genetic variants for rotator cuff tearing and repair in high-risk pedigrees.JSES international · 2024Article
- Anterolateral Acromioplasty Reduces Gliding Resistance Between the Supraspinatus Tendon and the Coracoacromial Arch in a Cadaveric Model.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Abnormal Laboratory Values for Metabolic and Hormonal Syndromes Are Prevalent Among Patients Undergoing Rotator Cuff Repair.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Current Understanding and New Advances in the Surgical Management of Reparable Rotator Cuff Tears: A Scoping Review.Journal of clinical medicine · 2023Article
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- The role of familial predisposition in imaging-confirmed atraumatic rotator cuff tears.Journal of shoulder and elbow surgery · 2022Article
- "Current concepts and expert practice report: Augmentation of rotator cuff repairs".Journal of clinical orthopaedics and trauma · 2021Article
- Footprint size matters: wider coronal greater tuberosity width is associated with increased rates of healing after rotator cuff repair.JSES international · 2021Article
- Genetic Aspects in Shoulder Disorders.Revista brasileira de ortopedia · 2020Article
- SAP30BP gene is associated with the susceptibility of rotator cuff tear: a case-control study based on Han Chinese population.Journal of orthopaedic surgery and research · 2020Article
- Family Predisposition for Rotator Cuff Tear and Other Tendinopathies - A Case-Control Study.Revista brasileira de ortopedia · 2020Article
- Gene Expression in Torn Rotator Cuff Tendons Determined by RNA Sequencing.Orthopaedic journal of sports medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA genetic predisposition has been suggested to contribute to the risk for development of rotator cuff disease on the basis of observed family clusters of close relatives. We used a population-based resource combining genealogical data for Utah with clinical diagnosis data from a large Utah hospital to test the hypothesis of excess familial clustering for rotator cuff disease.
methodsThe Utah Population Database contains combined health and genealogical data on over two million Utah residents. Current Procedural Terminology, Fourth Revision, codes (29827, 23412, 23410, and 23420) and International Classification of Diseases, Ninth Revision, codes (726.1, 727.61, and 840.4) entered in patient records were used to identify patients with rotator cuff disease. We tested the hypothesis of excess familial clustering using two well-established methods (the Genealogical Index of Familiality test and the estimation of relative risks in relatives) in the overall study group (3091 patients) and a subgroup of the study group diagnosed before the age of forty years (652 patients).
resultsThe Genealogical Index of Familiality test in patients diagnosed before the age of forty years showed significant excess relatedness for individuals with rotator cuff disease in close and distant relationships (as distant as third cousins) (p = 0.001). The relative risk of rotator cuff disease in the relatives of patients diagnosed before the age of forty years was significantly elevated for second degree (relative risk = 3.66, p = 0.0076) and third degree (relative risk = 1.81, p = 0.0479) relatives.
conclusionsWe analyzed a set of patients with diagnosed rotator cuff disease and a known genealogy to describe the familial clustering of affected individuals. The observations of significant excess relatedness of patients and the significantly elevated risks to both close and distant relatives of patients strongly support a heritable predisposition to rotator cuff disease.
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