Evidence map›Paper›PMID 19411449›Full record

ArticleThe American journal of pathology2009

Stromal cell expression of caveolin-1 predicts outcome in breast cancer.

Erica K Sloan, Daniel R Ciocca, Normand Pouliot, Anthony Natoli, Christina Restall, Michael A Henderson, Mariel A Fanelli, Fernando D Cuello-Carrión, Francisco E Gago, Robin L Anderson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 189 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. What is new in cancer-associated fibroblast biomarkers?Cell communication and signaling : CCS · 2023
    Review
  16. Review
  17. Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease.Advances in experimental medicine and biology · 2023
    Review
  18. Article
  19. Article
  20. Review

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Erica K SloanPeter MacCallum Cancer Centre, Locked Bag #1, A'Beckett St., Melbourne, Victoria, Australia, 8006.
Daniel R Ciocca
Normand Pouliot
Anthony Natoli
Christina Restall
Michael A Henderson
Mariel A Fanelli
Fernando D Cuello-Carrión
Francisco E Gago
Robin L Anderson
Peter MacCallum Cancer Centre · AUUniversity of Melbourne · AUFundación para la Investigación, Docencia y Prevención del Cáncer · ARInstituto de Medicina y Biología Experimental de Cuyo · ARUniversidad Nacional de Cuyo · AR

Funding

Genes important in breast cancer metastasisR01CA090291 · NCI · PETER MACCALLUM CANCER CENTRE · PI ANDERSON, ROBIN L · 2001 to 2003
$405k
NCI NIH HHS R01 CA090291NCI NIH HHS R0I CA90291
6 · The paper itself

Abstract

Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.

Indexed as

AdultAgedAged, 80 and overAnimalsBiomarkers, TumorBreast NeoplasmsCaveolin 1Erb-b2 Receptor Tyrosine KinasesFemaleHumansKaplan-Meier EstimateMiceMice, KnockoutMice, TransgenicMiddle AgedNeoplasm InvasivenessBiomarkers, TumorCaveolin 1Erb-b2 Receptor Tyrosine KinasesFam89b protein, mouseReceptors, EstrogenReceptors, ProgesteroneReceptors, Virus

Identifiers

PMID19411449
PMCPMC2684169
OpenAlexW2006171435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.