ArticleThe journal of pain2009
Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder.
Article in The journal of pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Estrogen Status and Temporomandibular Disorders: A Systematic Review.International journal of environmental research and public health · 2026Pooled it
- Presence of bacterial DNA in synovial fluid from the temporomandibular joint in patients with temporomandibular joint disorders.Frontiers in oral health · 2026Article
- Oral Health and Sociodemographic Aspects in Transgender People: A Descriptive Exploratory Study.Journal of oral rehabilitation · 2025Article
- Concurrent Occurrence of Obsessive-Compulsive Disorder and Myofascial Pain Dysfunction Syndrome: A Case Series.Frontiers in dentistry · 2025Article
- A nomogram for predicting the risk of temporomandibular disorders in university students.BMC oral health · 2024Article
- Estrogen Hormones' Implications on the Physiopathology of Temporomandibular Dysfunction.Journal of clinical medicine · 2024Review
- Predicting temporomandibular disorders in adults using interpretable machine learning methods: a model development and validation study.Frontiers in bioengineering and biotechnology · 2024Article
- Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans.Frontiers in endocrinology · 2024Review
- Article
- The Role of Sex Hormones in Pain-Related Conditions.International journal of molecular sciences · 2023Review
- Article
- TMD in Females with Menstrual Disorders.International journal of environmental research and public health · 2021Article
- Profiling of Patients with Temporomandibular Disorders: Experience of One Tertiary Care Center.Acta stomatologica Croatica · 2021Article
- Is the Temporomandibular Joints' Reciprocal Clicking Related to the Morphology and Position of the Mandible, as Well as to the Sagittal Position of Lower Incisors?-A Case-Control Study.International journal of environmental research and public health · 2021Article
- Temporomandibular Joint Pathology of Wild Carnivores in the Western USA.Frontiers in veterinary science · 2021Article
- Morphology of the Temporomandibular Joints Regarding the Presence of Osteoarthritic Changes.International journal of environmental research and public health · 2020Article
- Estrogen Selectively Enhances TMJ Disc but Not Knee Meniscus Matrix Loss.Journal of dental research · 2019Article
- Estrogen receptor gene is associated with dental fluorosis in Brazilian children.Clinical oral investigations · 2019Article
- A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain.Scientific reports · 2018Article
- A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.European journal of pain (London, England) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
unlabelledTemporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (XbaI/PvuII) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and 100 control women without TMJD. Restriction fragment length polymorphisms of polymerase chain reaction products were used to analyze XbaI and PvuII SNPs in DNA fragments. A model directly characterizing specific DNA sequence variants based on the risk haplotypic structure implemented with the EM algorithm was used to analyze the data. The [GC] haplotype of the XbaI locus was significantly more prevalent in both TMJD groups when compared with the control group (P = .0012). Specifically, the [GC] haplotype was more prevalent within the painful TMJD group versus the control group (OR = 3.203, 95% CI = 1.633, 6.284) and in the TMJD no pain versus the control group (OR = 2.51, 95% CI = 1.267, 4.97). In conclusion, the presence of [GC] haplotype in the XbaI locus may increase the susceptibility of women to develop TMJD. PERSPECTIVE: This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. This finding may elucidate the interindividual differences in the contribution of estrogen to TMJD, the genetic influences on TMJD predisposition, and may serve as the basis for future treatment tailoring, which could enhance outcomes for these patients.
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Registered trials
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