ArticleNeuroscience research2009
Effects of lithium chloride on the gene expression profiles in Drosophila heads.
Article in Neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Behavioral and molecular disruptions in honey bees induced by lithium chloride exposure.Scientific reports · 2025Article
- Effects of lithium on mortality and metabolite profiles in Drosophila lithium-inducible SLC6 transporter mutants.Environmental toxicology and pharmacology · 2025Article
- Effects of lithium on aggression in Drosophila.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- TheFrontiers in neuroscience · 2021Article
- Lithium Content of 160 Beverages and Its Impact on Lithium Status inFoods (Basel, Switzerland) · 2020Article
- Drug synergy as a strategy for compression of morbidity in a Caenorhabditis elegans model of Alzheimer's disease.GeroScience · 2020Article
- Article
- Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models.Frontiers in molecular neuroscience · 2018Article
- Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment.Nature communications · 2017Article
- Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila.Psychopharmacology · 2016Article
- Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease.Frontiers in aging neuroscience · 2014Article
- Molecular basis of essential amino acid transport from studies of insect nutrient amino acid transporters of the SLC6 family (NAT-SLC6).Journal of insect physiology · 2012Review
- A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila.Neuroscience · 2009Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the individual genes whose transcript levels are most significantly altered by lithium, we analyzed the microarray data with stringent criteria (fold change>2; p<0.001) and evaluated the results by RT-PCR. This analysis identified 12 genes that encode proteins with various biological functions, including an enzyme responsible for amino acid metabolism and a putative amino acid transporter. Second, to uncover the biological pathways involved in lithium's action in the nervous system, we used less stringent criteria (fold change>1.2; FDR<0.05) and assigned the identified 66 lithium-responsive genes to biological pathways using DAVID (Database for Annotation, Visualization and Integrated Discovery). The gene ontology categories most significantly affected by lithium were amino acid metabolic processes. Taken together, these data suggest that amino acid metabolism is important for lithium's actions in the nervous system, and lay a foundation for future functional studies of lithium-responsive neurobiological processes using the versatile molecular and genetic tools that are available in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.