ReviewFrontiers in neuroendocrinology2009
Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.
Review in Frontiers in neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.International journal of molecular sciences · 2011Pooled it
- Postmortem mitochondrial membrane permeability transition assessment of apoptotic cell death in brain and liver of insulin resistant, ovariectomised rats.IBRO neuroscience reports · 2021Article
- Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogsWorld journal of biological chemistry · 2021Review
- δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways.Molecular neurobiology · 2019Article
- Effects of nicotine on markers of bone turnover in ovariectomized rats.The Pan African medical journal · 2019Article
- Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury, and sex difference.Animal models and experimental medicine · 2018Article
- Why estrogens matter for behavior and brain health.Neuroscience and biobehavioral reviews · 2017Review
- Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo.Redox biology · 2016Article
- Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS.Acta neuropathologica communications · 2016Article
- Article
- Neuroprotective effects of nonfeminizing estrogens in retinal photoreceptor neurons.Investigative ophthalmology & visual science · 2012Article
- Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta.PloS one · 2012Article
- Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques.Neuroscience · 2011Article
- Estrogen protection in Friedreich's ataxia skin fibroblasts.Endocrinology · 2011Article
- Hormesis and Female Sex Hormones.Pharmaceuticals (Basel, Switzerland) · 2011Review
- Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.Antioxidants & redox signaling · 2011Article
- Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration.Journal of toxicology · 2011Article
- Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner.Brain research · 2010Article
- Huntington's disease and mitochondrial alterations: emphasis on experimental models.Journal of bioenergetics and biomembranes · 2010Article
- Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy.Progress in brain research · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the present treatise, we provide evidence that the neuroprotective and mito-protective effects of estrogens are inexorably linked and involve the ability of estrogens to maintain mitochondrial function during neurotoxic stress. This is achieved by the induction of nuclear and mitochondrial gene expression, the maintenance of protein phosphatases levels in a manner that likely involves modulation of the phosphorylation state of signaling kinases and mitochondrial pro- and anti-apoptotic proteins, and the potent redox/antioxidant activity of estrogens. These estrogen actions are mediated through a combination of estrogens receptor (ER)-mediated effects on nuclear and mitochondrial transcription of protein vital to mitochondrial function, ER-mediated, non-genomic signaling and non-ER-mediated effects of estrogens on signaling and oxidative stress. Collectively, these multifaceted, coordinated action of estrogens leads to their potency in protecting neurons from a wide variety of acute insults as well as chronic neurodegenerative processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.