ArticleJournal of neuroimmunology2009
Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset.
Article in Journal of neuroimmunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A Systematic Review of the Neuropathologic Findings of Post-Viral Olfactory Dysfunction: Implications and Novel Insight for the COVID-19 Pandemic.American journal of rhinology & allergy · 2021Pooled it
- Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations.Frontiers in neuroscience · 2025Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
- Olfactory immune response to SARS-CoV-2.Cellular & molecular immunology · 2024Review
- Tripping on the edge of consciousness.Sleep advances : a journal of the Sleep Research Society · 2023Article
- In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection.Viruses · 2021Review
- Local sleep.Sleep medicine reviews · 2019Review
- The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.ACS chemical neuroscience · 2016Review
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.American journal of neurodegenerative disease · 2016Review
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease.American journal of neurodegenerative disease · 2016Review
- Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge in mice.Brain, behavior, and immunity · 2015Article
- Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion.Clinical microbiology reviews · 2014Review
- Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Molecular neurobiology · 2013Review
- Dysfunctional nucleus tractus solitarius: its crucial role in promoting neuropathogenetic cascade of Alzheimer's dementia--a novel hypothesis.Neurochemical research · 2012Review
- Article
- Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes.Brain, behavior, and immunity · 2012Article
- ATP and the purine type 2 X7 receptor affect sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Neuroinflammation resulting from covert brain invasion by common viruses - a potential role in local and global neurodegeneration.Medical hypotheses · 2010Article
- Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex.Brain research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Influenza virus invades the olfactory bulb (OB) and enhances cytokine mRNAs therein at the time of illness onset. Here we show that viral antigen immunoreactivity co-localized with glial markers in the OB but could not be detected in other brain areas. Interleukin 1beta- and tumor necrosis factor alpha-immunoreactivity co-localized with neuronal markers in olfactory and central autonomic systems, and the number of cytokine-immunoreactive neurons increased at the time of illness onset [15 h post-inoculation (PI)] but not before (10 h PI). These results suggest that the OB virus influences the brain cytokines and therefore the onset of illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.