ArticleEpilepsy research2009
Development of spike-wave seizures in C3H/HeJ mice.
Article in Epilepsy research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Combining residual U-Net and data augmentation for dense temporal segmentation of spike wave discharges in single-channel EEG.Scientific reports · 2026Article
- Absence seizures: Update on signaling mechanisms and networks.Epilepsia open · 2025Article
- Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy.Experimental neurology · 2024Article
- Modulation of pacemaker channel function in a model of thalamocortical hyperexcitability by demyelination and cytokines.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Perinatal Immune Activation Produces Persistent Sleep Alterations and Epileptiform Activity in Male Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- SWDreader: a wavelet-based algorithm using spectral phase to characterize spike-wave morphological variation in genetic models of absence epilepsy.Journal of neuroscience methods · 2015Article
- Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.Alzheimer's research & therapy · 2015Article
- Neuroprotection by spice-derived nutraceuticals: you are what you eat!Molecular neurobiology · 2011Review
- Is epilepsy a preventable disorder? New evidence from animal models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
C3H/HeJ mice have been reported to have relatively early onset of spike-wave discharges (SWD), and a defective AMPA receptor subunit Gria4 as the genetic cause. We investigated the time course of SWD development through serial EEG recordings in C3H/HeJ mice to better characterize this model. We found that at immature postnatal ages of 5-15 days, rare SWD-like events were observed at an average rate of 3 per hour, and with relatively broad spikes, irregular rhythm, slow frequency (5-6 Hz), and short duration (mean 1.75 s). This was followed by a transitional period of increasing SWD incidence, which then stabilized in mature animals at age 26-62 days, with SWD at an average rate of 45 per hour, narrower spike morphology, regular rhythm, higher frequency (7-8 Hz), and longer duration (mean 3.40s). This sequence of maturational changes in SWD development suggests that effects of early intervention could be tested in C3H/HeJ mice over the course of a few weeks, rather than a few months as in rats, greatly facilitating future research on anti-epileptogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.