Evidence map›Paper›PMID 19409634›Full record

ReviewTrends in biotechnology2009

Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.

John H Phan, Richard A Moffitt, Todd H Stokes, Jian Liu, Andrew N Young, Shuming Nie, May D Wang

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Tumor-Derived Lactate Creates a Favorable Niche for TumorFrontiers in cell and developmental biology · 2022
    Review
  6. Review
  7. Article
  8. Robotic DNA Nanostructures.ACS synthetic biology · 2020
    Review
  9. Convergence Science Arrives: How Does It Relate to Psychiatry?Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2017
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Cardiovascular genomics: a biomarker identification pipeline.IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society · 2012
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John H PhanDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, UA Whitaker Building 4106, Atlanta, GA 30332, USA.
Richard A Moffitt
Todd H Stokes
Jian Liu
Andrew N Young
Shuming Nie
May D Wang

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI WANG, ZHONG · 2005 to 2009
$18.4M
Nanotechnology Linking Biomarkers with Cancer BehaviorR01CA108468 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2008
$6.9M
Bioaffinity Nanoparticle Probes for Bioimaging (RMI)P20GM072069 · NIGMS · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2007
$2.6M
NCI NIH HHS R01 CA108468NCI NIH HHS U54 CA119338NCI NIH HHS U54CA119338NIGMS NIH HHS P20 GM072069
6 · The paper itself

Abstract

Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

Indexed as

Biomarkers, TumorComputational BiologyAntineoplastic ProtocolsCarcinoma, Renal CellHumansKidney NeoplasmsKnowledge BasesNanotechnologyNeoplasmsBiomarkers, Tumor

Identifiers

PMID19409634
PMCPMC3779321

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.