ArticleAtherosclerosis2009
Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men.
Article in Atherosclerosis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Asthma is associated with atherosclerotic artery changes.PloS one · 2017Trial
- Interplay of the nasal microbiome and epigenome among adolescents.Clinical epigenetics · 2026Article
- Association of estimated pulse wave velocity with asthma risk in middle-aged and older adults in China: a national cohort study.BMC public health · 2025Article
- Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian Randomization.Journal of the American Heart Association · 2025Article
- Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Advances in the development of new biomarkers for Alzheimer's disease.Translational neurodegeneration · 2022Review
- Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.BMC pulmonary medicine · 2019Article
- GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease.Respiratory research · 2017Observational
- Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer's Disease-Like Pathology, Blood-Brain Barrier Disruption, and Synaptic Disorder.Molecular neurobiology · 2016Article
- Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies.Journal of genetics · 2014Review
- Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study.Environmental health : a global access science source · 2014Article
- Pharmacogenetics of asthma controller treatment.The pharmacogenomics journal · 2013Article
- The Association Study between Twenty One Polymorphisms in Seven Candidate Genes and Coronary Heart Diseases in Chinese Han Population.PloS one · 2013Article
- Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.The Journal of nutrition · 2012Article
- Article
- Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.BMC medical genetics · 2011Article
- Blood-based biomarkers of microvascular pathology in Alzheimer's disease.Experimental gerontology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundInflammation and endothelial dysfunction are important risk factors for cardiovascular disease (CVD). We hypothesized that candidate genes selected for a study of asthma and chronic obstructive pulmonary disorder (COPD) are associated with markers of systemic inflammation and endothelial dysfunction in an aging population.
methodsPlasma levels of circulating C-reactive protein (CRP), fibrinogen, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were obtained from 679 elderly male participants in the Normative Aging Study. Blood samples were analyzed for 202 single nucleotide polymorphisms (SNPs) in 25 candidate genes and included both haplotype tagSNPs and functional SNPs based on literature review. Data were stratified into discovery and replication cohorts for 2-stage analysis. In the discovery cohort, the relationship between biomarker level and genotype was analyzed using linear mixed effects with random intercepts for each subject and models were adjusted for age and BMI. A positive outcome in the discovery cohort was defined as a p-value <0.1 for the SNP. SNPs that met this criterion were analyzed in the replication cohort and confirmed for those which met a criterion of significance (p<0.025).
resultsIn our analyses, SNPs in the CRHR1, ITPR2, and VDR genes met significance criteria.
conclusionsOur results suggest that genes thought to play a role in the pathogenesis of asthma and COPD may influence levels of serum markers of inflammation and endothelial dysfunction via novel SNP associations which have not previously been associated with cardiovascular disease.
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