ArticleHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2009
Plasma CRP levels in premenopausal women with major depression: a 12-month controlled study.
Article in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Association between triglyceride and depression: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.Psychological medicine · 2019Pooled it
- Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder.Brain, behavior, and immunity · 2015Pooled it
- Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults.PloS one · 2013Trial
- Assessing the association between combined oral contraceptive use, selected biomarkers, and depressive episodes among premenopausal women: a protocol for a systematic review and meta-analysis.Systematic reviews · 2026Article
- Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy.The Journal of pharmacology and experimental therapeutics · 2020Review
- Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.Psychoneuroendocrinology · 2018Article
- Dietary treatment options for depression among diabetic patient, focusing on macronutrients.Journal of diabetes research · 2013Review
- Socioeconomic status, race, and bone turnover in the Midlife in the US Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Inflammatory biomarkers and depression.Neurotoxicity research · 2011Review
- Major depressive disorder is a risk factor for low bone mass, central obesity, and other medical conditions.Dialogues in clinical neuroscience · 2011Review
- Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study.The Journal of clinical psychiatry · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
C-reactive protein (CRP), an inflammatory marker of cardiovascular risk, is often elevated in major depressive disorder (MDD). The magnitude and consistency of this elevation have not been previously characterized in premenopausal women with MDD. The aim of the study was to prospectively assess plasma CRP levels, body composition, endocrine and metabolic parameters, and depressive status in premenopausal women with MDD (n=77) and controls (n=41), aged 21 to 45. Women were enrolled in a 12-month, controlled study of bone turnover, the P.O.W.E.R. ( Premenopausal, Osteoporosis, Women, Al Endronate, Dep Ression) Study. Blood samples were taken at Baseline, Month 6, and Month 12. Most subjects with MDD were in clinical remission. These women tended to have consistently higher CRP levels than controls over 12 months (p=0.077). BMI was positively related to log[CRP] in women with MDD only. Nine women with MDD had CRP levels greater than 10 mg/l, a value associated with a very high cardiovascular risk. This subset was obese and had significantly higher triglycerides, total cholesterol, LDL-cholesterol, fasting insulin, and HOMA-IR than the rest of women with MDD. The variations in CRP levels over time were high (intra- and inter-individual coefficients of variations of approximately 30-50% and approximately 70-140%, respectively). No control had CRP levels greater than 10 mg/l. Depression was associated with increased plasma CRP in women with MDD. The clinical significance of abnormal plasma CRP for cardiovascular risk needs to be assessed in large prospective studies of women with depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.