ArticleEuropean journal of nuclear medicine and molecular imaging2009
Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas).
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Compartmental modeling for blood flow quantification from dynamicAnnals of nuclear medicine · 2025Pooled it
- Added value of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Impact of improved attenuation correction on 18F-FDG PET/MR hybrid imaging of the heart.PloS one · 2019Trial
- Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up.European heart journal · 2017Trial
- Left ventricular vascular and metabolic adaptations to high-intensity interval and moderate intensity continuous training: a randomized trial in healthy middle-aged men.The Journal of physiology · 2016Trial
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Complete somatostatin-induced insulin suppression combined with heparin loading does not significantly suppress myocardial 18F-FDG uptake in patients with suspected cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Trial
- Quantification of absolute myocardial perfusion in patients with coronary artery disease: comparison between cardiovascular magnetic resonance and positron emission tomography.Journal of the American College of Cardiology · 2012Trial
- Cardiovascular imaging with total-body PET.The British journal of radiology · 2026Review
- Organ-Specific Perfusion Response to Adenosine as Measured Using Total-Body PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Intra-Individual Variability of Myocardial Blood Flow and Flow Reserve Assessed by [Diagnostics (Basel, Switzerland) · 2026Article
- Automated long axial field of view PET image processing and kinetic modelling with the TurBO toolbox.European journal of nuclear medicine and molecular imaging · 2026Article
- Homogeneity of the coronary microcirculation in angina with non-obstructive coronary artery disease.European heart journal. Cardiovascular Imaging · 2025Article
- Investigation of a deep learning-based reconstruction approach utilizing dual-view projection for myocardial perfusion SPECT imaging.American journal of nuclear medicine and molecular imaging · 2025Article
- Quantitative cardiac CT perfusion: physiologically-inspired model and identifying microvascular disease from discordant CTA CAD-RADS.Frontiers in cardiovascular medicine · 2025Article
- Myocardial blood flow in newly diagnosed breast cancer patients at rest and during exercise.iScience · 2024Article
- The effects of myocardial bridging on two-dimensional myocardial strain during dobutamine stress echocardiography.The international journal of cardiovascular imaging · 2024Article
- Feasibility of shortening scan duration ofEJNMMI physics · 2024Article
- An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?EJNMMI research · 2023Review
- Adenosine-induced splenic switch-off on [EJNMMI research · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCarimas (Cardiac Image Analysis System) is a new software package developed at the Turku PET Centre for the quantitation of PET studies of the heart with a broad range of tracers. The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation using (15)O-labelled water.
methodsFour observers with various levels of experience in nuclear medicine independently analysed 20 MP studies (10 rest flow: "rest", 10 adenosine-induced hyperaemia: "stress"). Each study was analysed twice. The linear mixed model for repeated measures was fitted to the data to calculate intraclass correlation coefficients (ICC), differences between the repeats (the intraobserver differences) and differences between the observers (the interobserver differences). Also, Pearson correlation coefficients (r) were calculated and Bland-Altman plots were drawn. The reproducibility of MP was assessed on global, regional and segmental levels. Thereafter, this analysis was applied in 48 consecutive clinical patients with suspected coronary heart disease (CHD).
resultsFor the experienced observer the Pearson r for all segments was 0.974 at rest and 0.978 at stress (p < 0.0001), and the repeatability coefficients were 0.145 ml/g per min (15.5% of the average) and 0.389 ml/g per min (14.9%), correspondingly. The ICC reflected very good overall reproducibility. The intraobserver and interobserver differences were small, and the difference between the most and the least experienced observers at stress was 8.5% for the global MP. The clinical accuracy of the perfusion in the detection of CHD was excellent (positive predictive value 91% and negative predictive value 88%) against invasive angiography.
conclusionThe results demonstrate high reproducibility of myocardial perfusion quantitation with (15)O-labelled water PET using Carimas. The results support the feasibility of robust analysis and good clinical accuracy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.