ArticleObesity (Silver Spring, Md.)2009
Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study.
Article in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Pooled it
- Genome-wide association study identifies multiple loci influencing human serum metabolite levels.Nature genetics · 2012Pooled it
- High prevalence of obesity-related hypertension among adults aged 40 to 79 years in Southwest China.Scientific reports · 2019Trial
- Prevalence and related factors of abdominal obesity among urban adults aged 35 to 79 years in southwest China.Frontiers in public health · 2023Article
- Identification of genetic loci simultaneously associated with multiple cardiometabolic traits.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
- High prevalence and low awareness of hyperuricemia in hypertensive patients among adults aged 50-79 years in Southwest China.BMC cardiovascular disorders · 2022Article
- Article
- Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study.Genetic epidemiology · 2021Article
- Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.BMC genomics · 2020Article
- Prevalence, awareness, treatment, and control of hypertension in southwestern China.Scientific reports · 2019Article
- Association of BUD13-ZNF259-APOA5-APOA1-SIK3 cluster polymorphism in 11q23.3 and structure of APOA5 with increased plasma triglyceride levels in a Korean population.Scientific reports · 2019Article
- Heritability and Genome-Wide Association Study of Plasma Cholesterol in Chinese Adult Twins.Frontiers in endocrinology · 2018Article
- Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.International journal of obesity (2005) · 2016Article
- Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome.International journal of obesity (2005) · 2016Article
- Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians.Journal of lipid research · 2016Article
- Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC).PloS one · 2015Article
- Missing heritability of common diseases and treatments outside the protein-coding exome.Human genetics · 2014Review
- The role of SNP-loop diuretic interactions in hypertension across ethnic groups in HyperGEN.Frontiers in genetics · 2013Article
- The continuing value of twin studies in the omics era.Nature reviews. Genetics · 2012Review
- Association of adipokines with blood pressure in rural Chinese adolescents.Journal of human hypertension · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
The increasing prevalence of metabolic syndrome (MS) poses a serious public-health problem worldwide. Effective prevention and intervention require improved understanding of the factors that contribute to MS. We analyzed data on a large twin cohort to estimate genetic and environmental contributions to MS and to major MS components and their intercorrelations: waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglycerides (TGs), and high-density lipoprotein-cholesterol (HDL-C). We applied structural equation modeling to determine genetic and environmental structure of MS and its major components, using 1,617 adult female twin pairs recruited from rural China. The heritability estimate for MS was 0.42 (95% confidence interval (CI): 0.00-0.83) in this sample with low MS prevalence (4.4%). For MS components, heritability estimates were statistically significant and ranged from 0.13 to 0.64 highest for WC, followed by TG, SBP, DBP, HDL-C, and FPG. HDL-C was mainly influenced by common environmental factors (0.62, 95% CI: 0.58-0.62), whereas the other five MS components were largely influenced by unique environmental factors (0.32-0.44). Bivariate Cholesky decomposition analysis indicated that the clinical clustering of MS components may be explained by shared genetic and/or environmental factors. Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology.
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Registered trials
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