ArticleNature2009
Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed.
- Spatiotemporal all-optical diffractive neural networks empowered by spatiotemporal light field manipulation.Light, science & applications · 2026Article
- Hadamard Matrix Slicing Single-Pixel Imaging: Establishing a Linear-Array-Inspired Paradigm for N-fold Acceleration Single-Pixel Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reconfigurable single-shot spectroscopy reaching 86 femtometers resolution.Nature communications · 2026Article
- Angular spectrum-encoded single-shot ultrafast photography.Light, science & applications · 2026Article
- Spectral-acoustic-coordinated astigmatic metalens for wide field-of-view and high spatiotemporal resolution 3D imaging.Light, science & applications · 2026Article
- Single-pixel imaging flow cytometry for biomedical research.Inflammation and regeneration · 2025Review
- Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE).Light, science & applications · 2025Article
- High-speed fluorescence lifetime imaging microscopy: techniques, applications, and prospects.Biophotonics discovery · 2025Review
- Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second.Light, science & applications · 2025Article
- Neuromorphic-enabled video-activated cell sorting.Nature communications · 2024Article
- Review
- High-speed optical imaging with sCMOS pixel reassignment.Nature communications · 2024Article
- Review
- Scan-less microscopy based on acousto-optic encoded illumination.Nanophotonics (Berlin, Germany) · 2024Article
- Single-shot optical imaging with spectrum circuit bridging timescales in high-speed photography.Science advances · 2023Article
- Single-Photon Level Dispersive Fourier Transform: Ultrasensitive Characterization of Noise-Driven Nonlinear Dynamics.ACS photonics · 2023Article
- Differential phase-diversity electrooptic modulator for cancellation of fiber dispersion and laser noise.Nature communications · 2023Article
- Recent Advances in Single-Molecule Tracking and Imaging Techniques.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Ultrafast dynamic machine vision with spatiotemporal photonic computing.Science advances · 2023Article
- Morphological profiling by high-throughput single-cell biophysical fractometry.Communications biology · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrafast real-time optical imaging is an indispensable tool for studying dynamical events such as shock waves, chemical dynamics in living cells, neural activity, laser surgery and microfluidics. However, conventional CCDs (charge-coupled devices) and their complementary metal-oxide-semiconductor (CMOS) counterparts are incapable of capturing fast dynamical processes with high sensitivity and resolution. This is due in part to a technological limitation-it takes time to read out the data from sensor arrays. Also, there is the fundamental compromise between sensitivity and frame rate; at high frame rates, fewer photons are collected during each frame-a problem that affects nearly all optical imaging systems. Here we report an imaging method that overcomes these limitations and offers frame rates that are at least 1,000 times faster than those of conventional CCDs. Our technique maps a two-dimensional (2D) image into a serial time-domain data stream and simultaneously amplifies the image in the optical domain. We capture an entire 2D image using a single-pixel photodetector and achieve a net image amplification of 25 dB (a factor of 316). This overcomes the compromise between sensitivity and frame rate without resorting to cooling and high-intensity illumination. As a proof of concept, we perform continuous real-time imaging at a frame speed of 163 ns (a frame rate of 6.1 MHz) and a shutter speed of 440 ps. We also demonstrate real-time imaging of microfluidic flow and phase-explosion effects that occur during laser ablation.
Indexed as
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19407796What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.