ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02408510 (Pilot Project to Examine the Effects of Exercise on Nocturnal Lipolysis in Men and Women), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Project to Examine the Effects of Exercise on Nocturnal Lipolysis in Men and Women
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Impact of Sex on Left Ventricular Cardiac Adaptations to Endurance Training: a Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Cold-Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans.Diabetes, obesity & metabolism · 2026Article
- Catecholaminergic activity among young adults after high phosphorus intake during childhood and adolescence.Hormones (Athens, Greece) · 2026Article
- The location of physical activity determines its efficacy on Vitamin D status: Evidence from a meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Review
- The nature of sex differences in catecholamine-induced lipolysis in subcutaneous fat cells.iScience · 2025Article
- Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.Trends in endocrinology and metabolism: TEM · 2025Review
- Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness.Journal of clinical medicine · 2022Article
- Observational
- Using Dietary Macronutrient Patterns to Predict Sarcopenic Obesity in Older Adults: A Representative Korean Nationwide Population-Based Study.Nutrients · 2021Article
- Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.Nature reviews. Endocrinology · 2021Review
- Gender Differences in Cardiac Hypertrophy.Journal of cardiovascular translational research · 2020Review
- High fat diet induces sex-specific differential gene expression in Drosophila melanogaster.PloS one · 2019Article
- Lack of Day/Night variation in fibroblast growth factor 21 levels in young healthy men.International journal of obesity (2005) · 2015Article
- Amphetamine-Like Analogues in Diabetes: Speeding towards Ketogenesis.Case reports in endocrinology · 2015Article
- Adrenergic control of lipolysis in women compared with men.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity.Frontiers in endocrinology · 2014Review
- Sex differences in exercise-induced cardiac hypertrophy.Pflugers Archiv : European journal of physiology · 2013Review
- Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents.BMC pediatrics · 2012Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Women have lower circulating catecholamine levels during metabolic perturbations, such as exercise or hypoglycemia, but similar rates of systemic lipolysis. This suggests women may be more sensitive to the lipolytic action of catecholamines, while maintaining similar glucoregulatory effects. The aim of the present study, therefore, was to determine whether women have higher rates of systemic lipolysis compared with men in response to matched peripheral infusion of catecholamines, but similar rates of glucose turnover. Healthy, nonobese women (n = 11) and men (n = 10) were recruited and studied on 3 separate days with the following infusions: epinephrine (Epi), norepinephrine (NE), or the two combined. Tracer infusions of glycerol and glucose were used to determine systemic lipolysis and glucose turnover, respectively. Following basal measurements of substrate kinetics, the catecholamine infusion commenced, and measures of substrate kinetics continued for 60 min. Catecholamine concentrations were similarly elevated in women and men during each infusion: Epi, 182-197 pg/ml and NE, 417-507 pg/ml. There was a significant sex difference in glycerol rate of appearance and rate of disappearance with the catecholamine infusions (P < 0.0001), mainly due to a significantly greater glycerol turnover during the first 30 min of each infusion: glycerol rate of appearance during Epi was only 268 +/- 18 vs. 206 +/- 21 micromol/min in women and men, respectively; during NE, only 173 +/- 13 vs. 153 +/- 17 micromol/min, and during Epi+NE, 303 +/- 24 vs. 257 +/- 21 micromol/min. No sex differences were observed in glucose kinetics under any condition. In conclusion, these data suggest that women are more sensitive to the lipolytic action of catecholamines, but have no difference in their glucoregulatory response. Thus the lower catcholamine levels observed in women vs. men during exercise and other metabolic perturbations may allow women to maintain a similar or greater level of lipid mobilization while minimizing changes in glucose turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.