ReviewMolecular endocrinology (Baltimore, Md.)2009
Minireview: role of protein methylation and demethylation in nuclear hormone signaling.
Review in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The role of epigenetics in women's reproductive health: the impact of environmental factors.Frontiers in endocrinology · 2024Review
- Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-γ.Scientific reports · 2021Article
- A motif in HSP90 and P23 that links molecular chaperones to efficient estrogen receptor α methylation by the lysine methyltransferase SMYD2.The Journal of biological chemistry · 2018Article
- Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice.Scientific reports · 2017Article
- What's new in estrogen receptor action in the female reproductive tract.Journal of molecular endocrinology · 2016Review
- Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review.Addiction biology · 2016Review
- Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis.PPAR research · 2016Review
- The Helicase Activity of Hyperthermophilic Archaeal MCM is Enhanced at High Temperatures by Lysine Methylation.Frontiers in microbiology · 2015Article
- The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.The Journal of biological chemistry · 2014Article
- Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration.Frontiers in cellular neuroscience · 2014Review
- Review
- Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Epigenetics of neural repair following spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- Modulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modifications.Yonsei medical journal · 2013Review
- Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction.Molecular and cellular endocrinology · 2012Article
- The road less traveled: new views of steroid receptor action from the path of dose-response curves.Molecular and cellular endocrinology · 2012Review
- Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells.PPAR research · 2012Article
- Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification.PloS one · 2012Article
- Hypoxia-induced methylation of a pontin chromatin remodeling factor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Epigenetic codes of PPARγ in metabolic disease.FEBS letters · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nuclear hormone receptors (NRs) are transcription factors responsible for mediating the biological effects of hormones during development, metabolism, and homeostasis. Induction of NR target genes is accomplished through the assembly of hormone-bound NR complexes at target promoters and coincides with changes in histone modifications that promote transcription. Some coactivators and corepressors of NR can enhance or inhibit NR function by covalently modifying histones. One such modification is methylation, which plays important roles in transcriptional regulation. Histone methylation is catalyzed by histone methyltransferases and reversed by histone demethylases. Recent studies have uncovered the importance of these enzymes in the regulation of NR target genes. In addition to histones, these enzymes have nonhistone substrates and can methylate and demethylate NRs and coregulatory proteins in order to modulate their function. This review discusses recent progress in our understanding of the role of methylation and demethylation of histones, NRs, and their coregulators in NR-mediated transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.