Evidence map›Paper›PMID 19406976›Full record

Trial reportJournal of the American Society of Nephrology : JASN2009

Dietary phosphorus acutely impairs endothelial function.

Emi Shuto, Yutaka Taketani, Rieko Tanaka, Nagakatsu Harada, Masashi Isshiki, Minako Sato, Kunitaka Nashiki, Kikuko Amo, Hironori Yamamoto, Yukihito Higashi and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03841786 (Effect of Phosphorus Additives on the Metabolome in Healthy Adults), which is not on this map. Cited by 194 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 4 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03841786 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Phosphorus Additives on the Metabolome in Healthy Adults

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2019 to 2022Enrolled30ConditionsMetabolic Syndrome, Insulin Sensitivity, Cardiovascular DiseasesArmsPhosphorus-supplemented study diet, Control Diet
3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 4 syntheses or guidelines pooled it, 406 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects.Journal of the American Society of Nephrology : JASN · 2018
    Trial
  10. Trial
  11. Impact of Phosphorus-Based Food Additives on Bone and Mineral Metabolism.The Journal of clinical endocrinology and metabolism · 2015
    Trial
  12. Trial
  13. Trial
  14. Cardiovascular effects of sevelamer in stage 3 CKD.Journal of the American Society of Nephrology : JASN · 2013
    Trial
  15. Trial
  16. Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.Hemodialysis international. International Symposium on Home Hemodialysis · 2011
    Trial
  17. Article
  18. Observational
  19. Review
  20. Review

134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Emi ShutoDepartment of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.
Yutaka Taketani
Rieko Tanaka
Nagakatsu Harada
Masashi Isshiki
Minako Sato
Kunitaka Nashiki
Kikuko Amo
Hironori Yamamoto
Yukihito Higashi
Yutaka Nakaya
Eiji Takeda
Tokushima University · JPHiroshima University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acute effect of phosphorus loading on endothelial function in vitro and in vivo. Exposing bovine aortic endothelial cells to a phosphorus load increased production of reactive oxygen species, which depended on phosphorus influx via sodium-dependent phosphate transporters, and decreased nitric oxide production via inhibitory phosphorylation of endothelial nitric oxide synthase. Phosphorus loading inhibited endothelium-dependent vasodilation of rat aortic rings. In 11 healthy men, we alternately served meals containing 400 mg or 1200 mg of phosphorus in a double-blind crossover study and measured flow-mediated dilation of the brachial artery before and 2 h after the meals. The high dietary phosphorus load increased serum phosphorus at 2 h and significantly decreased flow-mediated dilation. Flow-mediated dilation correlated inversely with serum phosphorus. Taken together, these findings suggest that endothelial dysfunction mediated by acute postprandial hyperphosphatemia may contribute to the relationship between serum phosphorus level and the risk for cardiovascular morbidity and mortality.

Indexed as

AdultAnimalsBrachial ArteryCardiovascular DiseasesCattleCells, CulturedCross-Over StudiesDisease Models, AnimalDouble-Blind MethodEndothelium, VascularHumansHyperphosphatemiaMaleNitric OxideNitric Oxide Synthase Type IIIOxidative StressNitric OxideNitric Oxide Synthase Type IIIPhosphorusPhosphorus, DietaryReactive Oxygen Species

Identifiers

PMID19406976
PMCPMC2709683
OpenAlexW2117885860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.