ArticleEndocrinology2009
Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 95 citations in OpenAlex.
- Intact mTOR signaling in gastric X/A-like cells is required for bone homeostasis.Frontiers in endocrinology · 2026Article
- Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin.Biology of sex differences · 2024Article
- Article
- The pressure not to eat.Nature metabolism · 2024Article
- Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.Nature metabolism · 2024Article
- Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.The Journal of clinical investigation · 2022Article
- Aberrant branched-chain amino acid catabolism in cardiovascular diseases.Frontiers in cardiovascular medicine · 2022Review
- Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.Neural plasticity · 2022Article
- Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization.Journal of cellular physiology · 2021Article
- Effects of Des-acyl Ghrelin on Insulin Sensitivity and Macrophage Polarization in Adipose Tissue.Journal of translational internal medicine · 2021Article
- Ghrelin Based Therapy of Metabolic Diseases.Current medicinal chemistry · 2021Review
- mTOR Pathway is Involved in Energy Homeostasis Regulation as a Part of the Gut-Brain Axis.International journal of molecular sciences · 2020Review
- Electroacupuncture Upregulated Ghrelin in Rats with Functional Dyspepsia via AMPK/TSC2/Rheb-Mediated mTOR Inhibition.Digestive diseases and sciences · 2020Article
- Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3-mechanistic target of rapamycin signaling.Acta pharmaceutica Sinica. B · 2020Article
- Ghrelin and liver disease.Reviews in endocrine & metabolic disorders · 2020Review
- Physiological Effect of Ghrelin on Body Systems.International journal of endocrinology · 2020Review
- Mechanisms controlling hormone secretion in human gut and its relevance to metabolism.The Journal of endocrinology · 2019Review
- Transcriptome analysis for identifying possible causes of post-reproductive death of Sepia esculenta based on brain tissue.Genes & genomics · 2019Article
- mTOR Signaling in X/A-Like Cells Contributes to Lipid Homeostasis in Mice.Hepatology (Baltimore, Md.) · 2019Article
- A Novel Stomach-Pancreas Connection: More than Physical.EBioMedicine · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate food intake. Mammalian target of rapamycin (mTOR) is an intracellular fuel sensor critical for cellular energy homeostasis. Here we showed the reciprocal relationship of gastric mTOR signaling and ghrelin during changes in energy status. mTOR activity was down-regulated, whereas gastric preproghrelin and circulating ghrelin were increased by fasting. In db/db mice, gastric mTOR signaling was enhanced, whereas gastric preproghrelin and circulating ghrelin were decreased. Inhibition of the gastric mTOR signaling by rapamycin stimulated the expression of gastric preproghrelin and ghrelin mRNA and increased plasma ghrelin in both wild-type and db/db mice. Activation of the gastric mTOR signaling by l-leucine decreased the expression of gastric preproghrelin and the level of plasma ghrelin. Overexpression of mTOR attenuated ghrelin promoter activity, whereas inhibition of mTOR activity by overexpression of TSC1 or TSC2 increased its activity. Ghrelin receptor antagonist d-Lys-3-GH-releasing peptide-6 abolished the rapamycin-induced increment in food intake despite that plasma ghrelin remained elevated. mTOR is therefore a gastric fuel sensor whose activity is linked to the regulation of energy intake through ghrelin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.