ArticleThe Journal of physiology2009
Fetal cerebral blood flow, electrocorticographic activity, and oxygenation: responses to acute hypoxia.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.The Journal of physiology · 2026Review
- Ultrasound Diagnosis and Near-Infrared Spectroscopy in the Study of Encephalopathy in Neonates Born under Asphyxia: Narrative Review.Children (Basel, Switzerland) · 2024Review
- Fetal brain response to worsening acidosis: an experimental study in a fetal sheep model of umbilical cord occlusions.Scientific reports · 2023Article
- Evolution of early cerebral NIRS in hypoxic ischaemic encephalopathy.Acta paediatrica (Oslo, Norway : 1992) · 2022Observational
- Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses.Frontiers in physiology · 2022Review
- The Role of Extracellular Vesicles in the Developing Brain: Current Perspective and Promising Source of Biomarkers and Therapy for Perinatal Brain Injury.Frontiers in neuroscience · 2021Review
- Long-Term Hypoxia Negatively Influences CaFrontiers in physiology · 2021Article
- Comparison of Chemical Exchange Saturation Transfer Imaging with Diffusion-weighted Imaging and Magnetic Resonance Spectroscopy in a Rat Model of Hypoxic-ischemic Encephalopathy.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020Article
- Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep.The Journal of physiology · 2017Article
- Long-term hypoxia increases calcium affinity of BK channels in ovine fetal and adult cerebral artery smooth muscle.American journal of physiology. Heart and circulatory physiology · 2015Article
- Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia.PloS one · 2015Article
- The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.Advances in experimental medicine and biology · 2014Article
- Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity.Current vascular pharmacology · 2013Review
- Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries.PloS one · 2013Article
- Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia.AJNR. American journal of neuroradiology · 2011Article
- Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Maturation and the role of PKC-mediated contractility in ovine cerebral arteries.American journal of physiology. Heart and circulatory physiology · 2009Article
- Fetal hypoxia insults and patterns of brain injury: insights from animal models.Clinics in perinatology · 2009Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Arterial blood gases are critical in regulation of cerebral blood flow (CBF) and cerebral metabolic rate for O(2) (CMRO(2)). However, the relation of these variables to cortical tissue (t ), and electrocorticographic (ECoG) activity (high voltage low frequency, HVLF, versus low voltage high frequency, LVHF), are not well defined. In the fetus, we tested the hypothesis that ECoG pattern is associated closely with cerebral oxygenation. In fetal sheep (n = 8) with laser Doppler flowmeter, fluorescent O(2) probe and ECoG electrodes, we measured laser Doppler CBF (LD-CBF), tP(O2), ECoG and spectral edge frequency-90 (SEF(90)) in response to 40 min isocapnic hypoxia. In the normoxic fetus, LD-CBF and CMRO(2) correlated highly with ECoG state. With a shift from HVLF to LVHF, tP(O2) decreased followed by increased LD-CBF (18%) and CMRO(2) (13%). With acute hypoxia (P(aO2)= 12 +/- 1 Torr), tp(O2) decreased toapproximately 3 Torr, LD-CBF increased 48 +/- 10%, ECoG shifted to chiefly the HVLF state, SEF(90) decreased approximately 15%, and CMRO(2) decreased approximately 20% (P < 0.05 for each). For the normoxic fetus, CBF was closely related to ECoG state, but this association was less evident during acute hypoxia. We speculate that, in the otherwise stressed fetus, acute hypoxia may further compromise cerebral oxygenation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.