ArticleThe Journal of physiology2009
TRPV1 channels control synaptic plasticity in the developing superior colliculus.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- A journey from molecule to physiology andFrontiers in pharmacology · 2023Review
- Involvement of transient receptor potential channels in ocular diseases: a narrative review.Annals of translational medicine · 2022Article
- Article
- Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators.Frontiers in molecular biosciences · 2022Article
- Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease.Frontiers in cellular neuroscience · 2022Review
- Receptor-Dependent and Independent Regulation of Voltage-Gated CaInternational journal of molecular sciences · 2021Review
- Personalized TMS: role of RNA genotyping.Mental illness · 2019Article
- Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion.Scientific reports · 2018Article
- Glutamate receptor GluA1 subunit is implicated in capsaicin induced modulation of amygdala LTP but not LTD.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Endocannabinoid-LTP Mediated by CB1 and TRPV1 Receptors Encodes for Limited Occurrences of Coincident Activity in Neocortex.Frontiers in cellular neuroscience · 2018Article
- TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.Nature communications · 2017Article
- Article
- Differences in chloride gradients allow for three distinct types of synaptic modulation by endocannabinoids.Journal of neurophysiology · 2016Article
- Inhibition of TRPV1 channels enables long-term potentiation in the entorhinal cortex.Pflugers Archiv : European journal of physiology · 2016Article
- Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity.Neural plasticity · 2016Review
- Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity.The Journal of physiology · 2015Article
- Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress.Channels (Austin, Tex.) · 2015Article
- Article
- Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Long-term depression (LTD) in the rodent superior colliculus (SC) is regarded as a model of synaptic refinement because it can be induced during development but not in adults. We investigated the role of transient receptor potential vanilloid type-1 (TRPV1) channels in this type of synaptic plasticity. Experiments were carried out in pigmented mice aged between postnatal day 8 (P8) and 42 (P42) and in adult mice. Retinal axons to the SC were labelled by injection of cholera toxin-beta (CTbeta) into the eye. Immunohistochemical staining for CTbeta, TRPV1 and markers of glutamatergic and GABAergic cells and fibres (VGLUT1 and VGAT or GAD65, respectively) was performed by using multiple immunofluorescence. This showed that both glutamatergic retinal afferents to, and some GABAergic neurones in, the superficial SC are TRPV1 positive in juvenile but not adult mice. Field potential recordings were made from the superficial grey layer in parasagittal SC slices, and LTD (76 +/- 8% of control responses) was induced with a 50 Hz, 20 s tetanus. Activation of TRPV1 with resiniferatoxin also reduced field potential amplitude to 84 +/- 8% of control values. Blockade of TRPV1 with the selective antagonist 5'-iodo-resiniferatoxin prevented the induction of LTD (98 +/- 4% of control values), but did not cause its reversal if LTD was already established. N-acylphosphatidylethanolamine-specific phospholipase D and 12-lipoxygenase, two proposed endovanilloid biosynthesizing enzymes, were co-expressed with TRPV1 in the SC at P14 and P28. These results suggest that TRPV1 modulates retinocollicular responses in the developing SC and is activated during tetanic stimulation by endovanilloid ligands to participate in the induction of LTD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.