ArticleAJNR. American journal of neuroradiology2009
CT angiography for brain death diagnosis.
Article in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045407 (Computed Tomography Angiography Accuracy in Brain Death Diagnosis), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Computed Tomography Angiography Accuracy in Brain Death Diagnosis
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Diagnostic accuracy of ancillary tests for death by neurologic criteria: a systematic review and meta-analysis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Pooled it
- Computed tomography angiography in the diagnosis of brain death: a systematic review and meta-analysis.Neurocritical care · 2014Pooled it
- Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death.The Cochrane database of systematic reviews · 2014Pooled it
- Death by neurologic criteria: a nuclear medicine approach based on the 2023 AAN/AAP/CNS/SCCM Guideline and 2025 SNMMI Procedure Standard.Pediatric radiology · 2026Review
- Catastrophic Hypoxic-Ischemic Brain Injury Following Influenza A Illness in a Young Woman: A Case Report.Cureus · 2026Article
- Review
- Diagnostic Sensitivity of the Revised Venous System in Brain Death in Children.Tomography (Ann Arbor, Mich.) · 2025Article
- Computed tomography angiography in the diagnosis of brain death: Implementation and results in Germany.European journal of neurology · 2024Article
- Pictorial Review on Imaging Findings in Cerebral CTP in Patients with Acute Stroke and Its Mimics: A Primer for General Radiologists.Diagnostics (Basel, Switzerland) · 2023Review
- Computed Tomography Angiography (CTA) in Selected Scenarios with Risk of Possible False-Positive or False-Negative Conclusions in Diagnosing Brain Death.Life (Basel, Switzerland) · 2022Review
- Cerebral blood vessels and perfusion in the pediatric brain death: five cases studied by neuroimaging.Neuroradiology · 2022Article
- Brain death in a vaccinated patient with COVID-19 infection.Clinical imaging · 2022Article
- Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure.Journal of clinical medicine · 2021Article
- Computed tomography angiography scoring systems and the role of skull defects in the confirmation of brain death.Scientific reports · 2021Article
- Assessment of Cerebral Circulatory Arrest via CT Angiography and CT Perfusion in Brain Death Confirmation.Korean journal of radiology · 2021Article
- South African guidelines on the determination of death.The Southern African journal of critical care : the official journal of the Critical Care Society · 2021Article
- Online Noninvasive Assessment of Human Brain Death by Near-Infrared Spectroscopy with Protocol of OAdvances in experimental medicine and biology · 2021Article
- Diagnostic Value of Perfusion MR Imaging as a Potential Ancillary Test for Brain Death.Journal of the Belgian Society of Radiology · 2020Article
- "Perimortem" total body CT-scan examination in severely injured children: an informative insight into the causes of death.International journal of legal medicine · 2020Article
- Brain computed tomography angiography in postcardiac arrest patients and neurologic outcome.Clinical and experimental emergency medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeLack of cerebral circulation is an important confirmatory test for brain death (BD). Conventional angiography remains the standard imaging method, but CT angiography (CTA) is emerging as an alternative. France accepts BD diagnoses relying on a score based on lack of opacification of 7 intracerebral vessels in CTA images. The purpose of this study was to validate the efficiency of this score and to evaluate the sensitivity of a novel 4-point CTA score in confirming BD. MATERIALS AND
methodsA prospective multicentric study was conducted during 12 months with 105 patients referred for CTA to confirm a clinical diagnosis of BD. Clinical data were recorded. CTA images were interpreted first by local radiologists at the referent center, resulting in a 7-point score based on lack of opacification of the pericallosal and cortical segments of the middle cerebral arteries (MCAs), internal cerebral veins (ICVs), and 1 great cerebral vein per patient and, second, by a consensus panel of 3 expert radiologists, blinded to the initial scores, resulting in novel 4-point scores based on the lack of opacification of the cortical segments of the MCAs and ICVs.
resultsInjection of contrast medium did not alter renal function. With the initial 7-point score, sensitivity was 62.8%. With the simplified 4-point score, sensitivity was 85.7% and specificity was 100%. Opacification of ICVs was absent in 98.1% of patients.
conclusionsLack of opacification in the cortical segments of the MCAs and internal veins in CTA is efficient and reliable for confirming BD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.