ArticleAmerican journal of ophthalmology2009
Peripapillary retinal nerve fiber layer thinning in patients with autosomal recessive cone-rod dystrophy.
Article in American journal of ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Peripapillary retinal nerve fibre layer thinning in patients with X-linked retinoschisis.BMJ open ophthalmology · 2024Article
- Cone Dystrophies: An Optical Coherence Tomography Angiography Study.Journal of clinical medicine · 2020Article
- White matter consequences of retinal receptor and ganglion cell damage.Investigative ophthalmology & visual science · 2014Article
- Optic Disc and Retinal Nerve Fibre Layer Changes in Parkinson's Disease.Neuro-ophthalmology (Aeolus Press) · 2013Article
- Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Quantification of peripapillary sparing and macular involvement in Stargardt disease (STGD1).Investigative ophthalmology & visual science · 2011Article
- Allelic and phenotypic heterogeneity in ABCA4 mutations.Ophthalmic genetics · 2011Review
- Retinal nerve fiber thickness measurements in choroideremia patients with spectral-domain optical coherence tomography.Ophthalmic genetics · 2011Article
- Spectral-domain OCT peripapillary retinal nerve fibre layer thickness measurements in patients with Stargardt disease.The British journal of ophthalmology · 2011Article
- The role of multimodal imaging and vision function testing inTherapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography in patients with autosomal recessive cone-rod dystrophy (CRD).
designCross-sectional study.
methodsEleven patients (22 eyes) with CRD were studied, including 4 patients with identified ABCA4 gene mutations. Peripapillary RNFL thickness was measured in 16 segments from 4 quadrants. The analyses were based on age and disc size-adjusted normative data. An abnormal thinning was considered when RNFL thickness measurements were less than the fifth percentile in at least 2 of 4 segments in a quadrant. Mean RNFL thickness was compared quantitatively with normative data obtained from 134 subjects.
resultsEight patients (73%) had peripapillary RNFL thinning in at least 1 quadrant of at least 1 eye, including 3 of 4 patients with known ABCA4 gene mutations. Peripapillary RNFL thinning in the temporal quadrant was seen most commonly in 11 (79%) of 14 eyes with thinning in at least 1 quadrant. Significant thinning of the overall peripapillary RNFL was observed in CRD patients compared with controls (P = .0002). Subgroup analysis showed that 8 (89%) of 9 patients who were older than 40 years had thinning in at least 1 quadrant of at least 1 eye.
conclusionsPeripapillary RNFL thinning was observed commonly in our patients with autosomal recessive CRD. The results confirm that the inner retinal structures can be affected in outer retinal disease. Careful evaluation of the inner retina may be important in determining the success rate of potential treatments for predominantly outer retinal diseases.
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