ArticleDevelopmental biology2009
Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Knockdown of PR-DUB subunit calypso in the developing Drosophila eye and wing results in mis-patterned tissues with altered size and shape.G3 (Bethesda, Md.) · 2025Article
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development.Molecular biology and evolution · 2025Article
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- Molecular Mechanism of Metformin Regulating the Regeneration of PlanarianInternational journal of molecular sciences · 2025Article
- Differential regulation of eye specification in Drosophila by Polycomb Group epigenetic repressors.Development (Cambridge, England) · 2025Article
- Dachshund and C-terminal Binding Protein bind directly duringmicroPublication biology · 2024Article
- Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.Development (Cambridge, England) · 2018Article
- Pax6 in Collembola: Adaptive Evolution of Eye Regression.Scientific reports · 2016Article
- Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae.PloS one · 2016Article
- Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.Scientific reports · 2015Article
- The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function.Protein & cell · 2015Article
- Digital expression profiling of the compartmentalized translatome of Purkinje neurons.Genome research · 2014Article
- The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.Developmental biology · 2014Article
- Cephalopod eye evolution was modulated by the acquisition of Pax-6 splicing variants.Scientific reports · 2014Article
- Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.Developmental biology · 2012Article
- Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development.Development (Cambridge, England) · 2012Article
- MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.PloS one · 2012Article
- Identification of retinal transformation hot spots in developing Drosophila epithelia.PloS one · 2010Article
- Retinal determination the beginning of eye development.Current topics in developmental biology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Pax genes encode DNA binding proteins that play pivotal roles in the determination of complex tissues. Members of one subclass, Pax6, function as selector genes and play key roles in the retinal development of all seeing animals. Mutations within the Pax6 homologs including fly eyeless, mouse Small eye and human Pax6 lead to severe retinal defects in their respective systems. In Drosophila eyeless and twin of eyeless, play non-redundant roles in the developing retina. One particularly interesting characteristic of these genes is that, although expression of either gene can induce ectopic eye formation in non-retinal tissues, there are differences in the location and frequencies at which the eyes develop. eyeless induces much larger ectopic eyes, at higher frequencies, and in a broader range of tissues than twin of eyeless. In this report we describe a series of experiments conducted in both yeast and flies that has identified protein modules that are responsible for the differences in tissue transformation. These domains appear to contain transcriptional activator and repressor activity of distinct strengths. We propose a model in which the selective presence of these activities and their relative strengths accounts, in part, for the disparity to which ectopic eyes are induced in response to the forced expression of eyeless and twin of eyeless. The identification of both transcriptional activator and repressor activity within the Pax6 protein furthers our understanding of how this gene family regulates tissue determination.
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