ArticleAnnals of clinical microbiology and antimicrobials2009
Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
Article in Annals of clinical microbiology and antimicrobials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Prevalence and correlation with clinical diseases of Helicobacter pylori cagA and vacA genotype among gastric patients from Northeast China.BioMed research international · 2014Trial
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- Helicobacter pylori Infection in Colombia: Phylogeny, Resistome, and Virulome.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Article
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- CagL polymorphisms D58/K59 are predominant inGut pathogens · 2019Article
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- vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.Journal of medical microbiology · 2018Article
- Unraveling the Novel Protective Effect of Patchouli Alcohol AgainstFrontiers in pharmacology · 2018Article
- Prevalence of SpecificJournal of clinical and diagnostic research : JCDR · 2017Article
- Low Rate ofJournal of clinical and diagnostic research : JCDR · 2017Article
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- High Frequency of vacA s1m2 Genotypes Among Helicobacter pylori Isolates From Patients With Gastroduodenal Disorders in Kermanshah, Iran.Jundishapur journal of microbiology · 2015Article
- The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population.BMC gastroenterology · 2014Article
- Gastric cancer research in Mexico: a public health priority.World journal of gastroenterology · 2014Review
- Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2, and oipA genotypes in patients with upper gastrointestinal diseases.Iranian journal of microbiology · 2014Article
- Prevalence of Helicobacter pylori vacA different genotypes in Isfahan, Iran.Advanced biomedical research · 2014Article
- Low frequency of cagA-positive Helicobacter pylori strains isolated from Iranian patients with MALT lymphoma.Internal and emergency medicine · 2013Article
- The immunohistochemistry and toluidine blue roles for Helicobacter pylori detection in patients with gastritis.Iranian biomedical journal · 2013Article
- Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer.BMC microbiology · 2011Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori has been strongly associated with chronic gastritis, peptic and duodenal ulcers, and it is a risk factor for gastric cancer. Three major virulence factors of H. pylori have been described: the vacuolating toxin (VacA), the cytotoxin-associated gene product (CagA) and the adhesion protein BabA2. Since considerable geographic diversity in the prevalence of H. pylori virulence factors has been reported, the aim of this work was to establish the H. pylori and vacA, cagA and babA2 gene status in 238 adult patients, from a marginal urban area of Mexico, with chronic gastritis.
methodsH. pylori was identified in cultures of gastric biopsies by nested PCR. vacA and cagA genes were detected by multiplex PCR, whereas babA2 gene was identified by conventional PCR.
resultsH. pylori-positive biopsies were 143 (60.1%). All H. pylori strains were vacA+; 39.2% were cagA+; 13.3% were cagA+ babA2+ and 8.4% were babA2+. Mexican strains examined possessed the vacA s1, m1 (43.4%), s1, m2 (24.5%), s2, m1 (20.3%) and s2, m2 (11.9%) genotypes.
conclusionThese results show that the Mexican patients suffering chronic gastritis we have studied had a high incidence of infection by H. pylori. Forty four percent (63/143) of the H. pylori strains analyzed in this work may be considered as highly virulent since they possessed two or three of the virulence markers analyzed: vacA s1 cagA babA2 (9.8%, 14/143), vacA s1 babA2 (4.9%, 7/143), and vacA s1 cagA (29.4%, 42/143). However, a statistically significant correlation was not observed between vacAs1, cagA and babA2 virulence markers (chi2 test; P > 0.05).
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