ReviewDrugs2009
Medical expulsive therapy for distal ureteral stones.
Review in Drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The influence of pre-stenting and drugs on the outcomes of ureteroscopy for kidney and ureteral stone disease: a systematic review and meta-analysis by the EAU Section of Endourology.World journal of urology · 2025Pooled it
- The safety and efficacy of doxazosin in medical expulsion therapy for distal ureteric calculi: A meta-analysis.PloS one · 2021Pooled it
- The efficacy and safety of silodosin for the treatment of ureteral stones: a systematic review and meta-analysis.BMC urology · 2016Pooled it
- Efficacy and safety of silodosin in the medical expulsion therapy for distal ureteral calculi: a systematic review and meta-analysis.British journal of clinical pharmacology · 2016Pooled it
- Evaluation of the efficacy and safety of either or both mirabegron and silodosin, as a medical expulsive therapy for distal ureteric stones.International urology and nephrology · 2024Trial
- Enhancing stone expulsion: The efficacy of combined medical therapy with tamsulosin and dexamethasone in renal colic patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Adrenoceptors in the Lower Urinary Tract.Handbook of experimental pharmacology · 2024Review
- Active metabolic lithiasis: A condition that requires proper evaluation and monitoring.Experimental and therapeutic medicine · 2022Article
- Evolving Role of Silodosin for the Treatment of Urological Disorders - A Narrative Review.Drug design, development and therapy · 2022Review
- Adrenoceptors-New roles for old players.British journal of pharmacology · 2019Article
- Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study.Arab journal of urology · 2016Article
- Medical expulsive treatment in pediatric urolithiasis.Turkish journal of urology · 2015Review
- The effect of smoking on spontaneous passage of distal ureteral stones.BMC urology · 2014Article
- The effect of tamsulosin, an alpha-1 receptor antagonist as a medical expelling agent in success rate of ureteroscopic lithotripsy.Nephro-urology monthly · 2014Article
- Comparing the efficacy of tamsulosin and silodosin in the medical expulsion therapy for ureteral calculi.Journal of clinical and diagnostic research : JCDR · 2013Article
- Spontaneous renal pelvis rupture: unexpected complication of urolithiasis expected to passage with observation therapy.Case reports in urology · 2013Article
- Management of ureteral calculi and medical expulsive therapy in emergency departments.Journal of emergencies, trauma, and shock · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although minimally invasive treatments for ureteral stones are efficacious, they are not free of complications and are associated with high cost. Medical expulsive therapy (MET) has recently emerged as an alternative strategy for the initial management of small distal ureteral stones. A MEDLINE search was undertaken to evaluate all currently available data on efficacy and safety of MET therapy in such patients. The specific mechanism of action on the ureteral smooth muscle and the emerging evidence of the efficacy (defined as either an increase in expulsion rate or a decrease in time to expulsion) and low-risk profile suggest that alpha-adrenergic receptor antagonists (alpha-blockers) and calcium channel antagonists should be the initial medical treatment in patients amenable to conservative therapy. NSAIDs and anticholinergics have not shown efficacy as single agents or in combination with alpha-blockers or nifedipine. Corticosteroids may provide a small additive effect when combined with either alpha-blockers or nifedipine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.