ReviewExperimental brain research2009
Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro.
Review in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.Inflammopharmacology · 2026Review
- Hypothalamic Neuromodulation and Control of the Dermal Surface Temperature of Livestock during Hyperthermia.Animals : an open access journal from MDPI · 2024Review
- Control of astrocytic CaBiological research · 2024Article
- Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands.Life science alliance · 2023Article
- TRPV3: Structure, Diseases and Modulators.Molecules (Basel, Switzerland) · 2023Review
- TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy.Frontiers in molecular neuroscience · 2022Review
- Pharmacological inhibition of the mitochondrial CaJournal of molecular and cellular cardiology · 2021Review
- The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- TRPV4: A Physio and Pathophysiologically Significant Ion Channel.International journal of molecular sciences · 2020Review
- TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Heat-resistant action potentials require TTX-resistant sodium channels NaThe Journal of general physiology · 2018Article
- Pharmacological dissection of the cellular mechanisms associated to the spontaneous and the mechanically stimulated ATP release by mesentery endothelial cells: roles of thrombin and TRPV.Purinergic signalling · 2018Article
- Analysis of Nociceptive Information Encoded in the Temporal Discharge Patterns of Cutaneous C-Fibers.Frontiers in computational neuroscience · 2016Article
- Blockade of transient receptor potential cation channel subfamily V member 1 promotes regeneration after sciatic nerve injury.Neural regeneration research · 2015Article
- Article
- Amplified cold transduction in native nociceptors by M-channel inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Inflammatory cytokines in experimental and human stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines.Arthritis research & therapy · 2011Review
- Nociceptors: the sensors of the pain pathway.The Journal of clinical investigation · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capsaicin receptor TRPV1 is a polymodal sensory transducer molecule in the pain pathway. TRPV1 integrates noxious heat, tissue acidosis and chemical stimuli which are all known to cause pain. Studies on TRPV1-deficient mice suggest that TRPV1 is essential for acid sensing by nociceptors and for thermal hyperalgesia in inflammation of the skin, but not for transducing noxious heat. After TRPV1, other TRPV channels were cloned with polymodal properties and sensitivity to noxious heat, named TRPV2, TRPV3 and TRPV4. While TRPV3 and TRPV4 are predominantly warm sensors, TRPV2's threshold is in the noxious range (>52 degrees C). However, mice deficient of TRPV2 and TRPV1 or TRPV3 or TRPV4 show no major impairment of noxious heat sensing. Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation. Antagonistic effects of the dye were subsequently described on many other TRP-channels, especially on the heat-sensitive ones of the vanilloid family, TRPV2, TRPV3 and TRPV4. In this study, we used the rat skin-nerve preparation to define the possible actions of ruthenium red on the proton, capsaicin and noxious heat activation of native polymodal nociceptors. Ruthenium red was found to suppress only the capsaicin-induced excitation and desensitization of these nerve endings. On the contrary, the proton and heat-induced discharge responses of the single fibres were not influenced. Additionally, we found that the dye concentration dependently increases the excitability of the neurons resulting in ongoing activity and burstlike discharge. These differential results are discussed in the light of recent findings from transgenic mouse models, and they point once more to major (pharmacological) differences between cellular models of nociception, including spinal ganglion neuron and transfected cell lines, and the real native nerve endings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.