SynthesisPsychopharmacology2009
The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.
Synthesis in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review.Acta neuropsychiatrica · 2024Pooled it
- Impaired reproduction after exposure to ADHD drugs: Systematic review of animal studies.The International journal of risk & safety in medicine · 2017Pooled it
- The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the treatment of adolescent sexual offenders with paraphilic disorders.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2016Guideline
- Impact of escitalopram on vagally mediated cardiovascular function in healthy participants: implications for understanding differential age-related, treatment emergent effects.Psychopharmacology · 2014Trial
- Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques.Behavioral neuroscience · 2013Trial
- Exploration of the associations between violent and aggressive behaviors risk and NHHR, TyG in patients with schizophrenia: an SHAP interpretable machine learning prediction and FAERS pharmacovigilance analysis.Lipids in health and disease · 2025Article
- High-carotenoid orange corn diet altered serotonin and dopamine activity in the brain while heat stress altered total antioxidant capacity in a sex dependent manner in Pekin ducks.Poultry science · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- Preening cups in duck housing are associated with an increase in central dopamine activity that suggests a negative affective state.Poultry science · 2024Article
- Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.Diseases (Basel, Switzerland) · 2024Article
- The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia.Medicina (Kaunas, Lithuania) · 2023Article
- Tryptophan Hydroxylase 2 Knockout Male Rats Exhibit a Strengthened Oxytocin System, Are Aggressive, and Are Less Anxious.ACS chemical neuroscience · 2022Article
- Neuroendocrine regulation of female aggression.Frontiers in endocrinology · 2022Review
- Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.Nature communications · 2021Article
- Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis.BMJ open · 2021Article
- Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).Hormones and behavior · 2021Article
- Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy.Personality neuroscience · 2019Review
- Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review.Frontiers in endocrinology · 2019Review
- Serotonin-specific lesions of the dorsal raphe disrupt maternal aggression and caregiving in postpartum rats.Behavioural brain research · 2018Article
- Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleThe role of serotonin (5-HT) on aggression has been extensively studied; nonetheless, the role of this neurotransmitter in aggression is still inconclusive.
objectivesThe current meta-analytical review investigated the role of increased 5-HT neurotransmission in aggression.
methodsPreclinical studies using serotonin reuptake inhibitors, 5-hydroxytryptophan, L-tryptophan, or serotonin (5-HT) to increase 5-HT levels were included in this meta-analysis. An overall effect of serotonin on aggression was calculated, and the role of several moderator variables was analyzed.
resultsA total of 218 effect sizes revealed that increased 5-HT had an overall significant inhibitory effect on aggression (r = 0.3). The results showed that increased 5-HT had the strongest inhibitory effect on aggression when (1) a specific strain or species (e.g., Long Evans) was used; (2) aggression was offensive or predatory and/or induced by administration of 5,7-dihydroxytryptamine or p-chlorophenylalanine; (3) zimelidine, sertraline, L-tryptophan, citalopram, or 5-HT were used to increase 5-HT; (4) treatment was acute; (5) long chronic treatment durations were used; and (6) time between last injection and behavior testing was within 8 h before or after peak plasma concentration of drug. In contrast, the results revealed that increased-5-HT-facilitated aggression could be predicted when (1) Wistar rats, (2) social isolation or stress to induce aggression, and/or (3) animals treated for less than 3 weeks were used.
conclusionsAlthough 5-HT has an overall inhibitory effect on aggression, the animal's genetic background, drug, treatment time, aggression inducing paradigm, and aggression type are critical variables that influence and modify this effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.