ArticlePsychopharmacology2009
Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prepulse inhibition in patients with bipolar disorder: a systematic review and meta-analysis.BMC psychiatry · 2019Pooled it
- Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.Actas espanolas de psiquiatria · 2025Review
- Sodium valproate improves sensorimotor gating deficit induced by sleep deprivation at low dosesTurkish journal of medical sciences · 2021Article
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Auditory startle response is normal in juvenile myoclonic epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy 'low and high gating' humans and relation to psychometry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- CRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents.Psychopharmacology · 2014Article
- Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.Psychopharmacology · 2013Article
- The relationship between acoustic startle response measures and cognitive functions in Japanese patients with schizophrenia.Neuromolecular medicine · 2012Article
- Lamotrigine effects sensorimotor gating in WAG/Rij rats.Journal of neurosciences in rural practice · 2012Article
- HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells.American journal of stem cells · 2012Article
- Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.PloS one · 2012Article
- Predictive animal models of mania: hits, misses and future directions.British journal of pharmacology · 2011Review
- Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse.Psychopharmacology · 2011Article
- Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy.Journal of psychopharmacology (Oxford, England) · 2011Article
- The effects of d-amphetamine, methylphenidate, sydnocarb, and caffeine on prepulse inhibition of the startle reflex in DBA/2 mice.Psychopharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleLithium and several antiepileptic drugs have mood-stabilizing effects in bipolar disorder and schizophrenia. Both disorders are characterized by deficits in prepulse inhibition (PPI) of the acoustic startle response.
objectivesUsing the DBA/2 model of naturally low PPI, which is reliably increased by antipsychotics, five mood stabilizers in clinical use were tested to determine whether they would also increase PPI in this model. All drugs were administered intraperitoneally (i.p.) 30 min before testing.
resultsLithium chloride (30 mg/kg), topiramate (100 and 300 mg/kg), carbamazepine (30, 60, and 100 mg/kg), valproic acid (178 and 316 mg/kg), and lamotrigine (3, 10, and 30 mg/kg) increased percent PPI. The antiepileptic drugs carbamazepine, valproic acid, and lamotrigine at high doses also decreased no-stimulus amplitudes and increased startle amplitudes. At high doses of carbamazepine, valproic acid, and lamotrigine, increases in percent PPI were independent of the increases in startle amplitude.
conclusionsThe demonstrated efficacy of five mood stabilizers in the DBA/2 model of naturally low PPI points to the translational value of this model in predicting therapeutic activity in schizophrenia and bipolar disorder of compounds with diverse mechanisms of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.