Evidence map›Paper›PMID 19404498›Full record

SynthesisJournal of the Medical Library Association : JMLA2009

Search strategies to identify information on adverse effects: a systematic review.

Su Golder, Yoon Loke

Abstract readEvaluation StudySystematic Review
In one paragraph

Synthesis in Journal of the Medical Library Association : JMLA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Search strategies to identify observational studies in MEDLINE and Embase.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Topical cyclosporine for atopic keratoconjunctivitis.The Cochrane database of systematic reviews · 2012
    Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Welcoming systematic reviews to the Journal of the Medical Library Association.Journal of the Medical Library Association : JMLA · 2014
    Article
  16. Article
  17. Article
  18. Using information mining of the medical literature to improve drug safety.Journal of the American Medical Informatics Association : JAMIA
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Su GolderCentre for Reviews and Dissemination, University of York, York, YO10 5DD, United Kingdom. spg3@york.ac.uk
Yoon Loke

Funding

Medical Research Council G0601692
6 · The paper itself

Abstract

objectivesThe review evaluated studies of electronic database search strategies designed to retrieve adverse effects data for systematic reviews.

methodsStudies of adverse effects were located in ten databases as well as by checking references, hand-searching, searching citations, and contacting experts. Two reviewers screened the retrieved records for potentially relevant papers.

resultsFive thousand three hundred thirteen citations were retrieved, yielding 19 studies designed to develop or evaluate adverse effect filters, of which 3 met the inclusion criteria. All 3 studies identified highly sensitive search strategies capable of retrieving over 95% of relevant records. However, 1 study did not evaluate precision, while the level of precision in the other 2 studies ranged from 0.8% to 2.8%. Methodological issues in these papers included the relatively small number of records, absence of a validation set of records for testing, and limited evaluation of precision.

conclusionsThe results indicate the difficulty of achieving highly sensitive searches for information on adverse effects with a reasonable level of precision. Researchers who intend to locate studies on adverse effects should allow for the amount of resources and time required to conduct a highly sensitive search.

Indexed as

Databases, FactualDrug-Related Side Effects and Adverse ReactionsVocabulary, ControlledAbstracting and IndexingGuidelines as TopicHumansInformation Storage and RetrievalMeta-Analysis as TopicPeriodicals as TopicQuality ControlResearch DesignReview Literature as Topic

Identifiers

PMID19404498
PMCPMC2670220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.