ArticleHFSP journal2007
Trapping the nematode on a micro chip for the future of science.
Article in HFSP journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
At the basis of neuroscience is the correlation between behavior and neural signals. This relationship is studied using a variety of techniques, including fluorescent intensity measurements of genetically encoded calcium indicators. The simple structure and conservation of some basic developmental pathways between vertebrates and Caenorhabditis elegans makes it an ideal model for studies employing this technique, but it has been difficult to apply neural stimuli in a controlled way to such a small organism. New microfabrication techniques allow the creation of "worm traps" via a combination of lithography and microfluidic regulation. These micro-scale devices have made possible the immobilization of nematodes in the absence of glue (which could affect the worms' neural activity), in addition to offering more control over the application and removal of stimuli than was possible in previous experimental setups. Chronis et al. link an increase in AVA (a type of motor neurons formed by bilaterally symmetric interneuron pairs) neural activity to the initiation of anterior-traveling body waves, and observed an increase in ASH (a type of sensory neurons responsible for a wide range of avoidance behaviors in response to chemical and physical stimulations) neural activity in response to stimulation by high osmotic strength solutions. The microfabrication developments described can be combined with recent advances in the biological sciences, in particular the developmental embryology, to yield solutions to important problems, such as the detection of low concentration substrates and the analysis of homeostasis and embryonic development.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.