Trial reportPloS one2009
Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study.
Trial report in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00194519 (Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples), which is not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples
Who cites it
59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Prevalence of HHV-6 Detection Among People Living with HIV: A Systematic Review and Meta-Analysis.Viruses · 2025Pooled it
- Pooled it
- Behavioral interventions for improving contraceptive use among women living with HIV.The Cochrane database of systematic reviews · 2016Pooled it
- Behavioral interventions for improving dual-method contraceptive use.The Cochrane database of systematic reviews · 2014Pooled it
- The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies.PLoS medicine · 2013Pooled it
- Concurrent sexual partnerships do not explain the HIV epidemics in Africa: a systematic review of the evidence.Journal of the International AIDS Society · 2010Pooled it
- Scale up of PrEP integrated in public health HIV care clinics: a protocol for a stepped-wedge cluster-randomized rollout in Kenya.Implementation science : IS · 2018Trial
- Prevalence of Herpes Simplex Virus 2 (HSV-2) infection and associated risk factors in a cohort of HIV negative women in Durban, South Africa.BMC research notes · 2016Trial
- A prospective study of the effect of pregnancy on CD4 counts and plasma HIV-1 RNA concentrations of antiretroviral-naive HIV-1-infected women.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Unreported antiretroviral use by HIV-1-infected participants enrolling in a prospective research study.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Trial
- Daily acyclovir to decrease herpes simplex virus type 2 (HSV-2) transmission from HSV-2/HIV-1 coinfected persons: a randomized controlled trial.The Journal of infectious diseases · 2013Trial
- Changes in HIV-1 subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Trial
- HIV testing and counseling leads to immediate consistent condom use among South African stable HIV-discordant couples.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters.AIDS research and human retroviruses · 2013Trial
- Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial.BMC infectious diseases · 2012Trial
- Contraceptive method and pregnancy incidence among women in HIV-1-serodiscordant partnerships.AIDS (London, England) · 2012Trial
- Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study.The Lancet. Infectious diseases · 2012Trial
- The importance of male partner involvement for women's acceptability and adherence to female-initiated HIV prevention methods in Zimbabwe.AIDS and behavior · 2011Trial
- Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.PloS one · 2011Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 15 institutions in 9 countries.
Funding
Abstract
backgroundThe Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort.
methodsHIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count >or=250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed.
resultsOf the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2-9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (<5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462cells/mcL and median HIV-1 plasma RNA was 4.2 log(10) copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log(10) copies/mL; p<0.001) and CD4 count (-0.25 and -0.55 log(10) copies/mL for CD4 350-499 and >500 relative to <350, respectively, p<0.001).
conclusionsThe Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission.
trial registrationClinicalTrials.gov NCT00194519.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.