ReviewNature reviews. Drug discovery2009
Targeting the CNS to treat type 2 diabetes.
Review in Nature reviews. Drug discovery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 101 citations in OpenAlex.
- Trial
- Activation of K(ATP) channels suppresses glucose production in humans.The Journal of clinical investigation · 2011Trial
- Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease.Neuroprotection (Chichester, England) · 2025Review
- Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.PLoS biology · 2025Article
- Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites.Biomedicines · 2022Review
- Hepatic glycogen participates in the regulation of hypothalamic pAkt/Akt ratio in high-sugar/high-fat diet-induced obesity.Metabolic brain disease · 2022Article
- Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine.Nature biomedical engineering · 2022Article
- Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications.Theranostics · 2022Review
- Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats.Frontiers in neuroscience · 2022Article
- Article
- Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.Cell metabolism · 2019Article
- The blood-brain barrier as an endocrine tissue.Nature reviews. Endocrinology · 2019Review
- The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia.Frontiers in aging neuroscience · 2019Article
- Mitochondrial Dynamics and Hypothalamic Regulation of Metabolism.Endocrinology · 2018Article
- Overactivity of Liver-Related Neurons in the Paraventricular Nucleus of the Hypothalamus: Electrophysiological Findings inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation.Journal of neuroendocrinology · 2017Article
- Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism.Frontiers in endocrinology · 2017Review
- Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?Journal of biomedical science · 2016Review
- Roles of the interorgan neuronal network in the development of metabolic syndrome.Diabetology international · 2016Article
- From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery.Nature reviews. Drug discovery · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Research on the role of peripheral organs in the regulation of glucose homeostasis has led to the development of various monotherapies that aim to improve glucose uptake and insulin action in these organs for the treatment of type 2 diabetes. It is now clear that the central nervous system (CNS) also plays an important part in orchestrating appropriate glucose metabolism, with accumulating evidence linking dysregulated CNS circuits to the failure of normal glucoregulatory mechanisms. There is evidence that there is substantial overlap between the CNS circuits that regulate energy balance and those that regulate glucose levels, suggesting that their dysregulation could link obesity and diabetes. These findings present new targets for therapies that may be capable of both inducing weight loss and improving glucose regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.