ArticleGenes and immunity2009
Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Unsupervised clustering of clinical and laboratory features of systemic lupus erythematosus: insights from a multicentre cohort.Lupus science & medicine · 2026Article
- Identification of NETs-related genes as diagnostic biomarkers in ischemic stroke using RNA sequencing and single-cell analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- The impact ofSaudi journal of biological sciences · 2023Article
- TheJournal of inflammation research · 2023Article
- Hydroxychloroquine is associated with lower platelet activity and improved vascular health in systemic lupus erythematosus.Lupus science & medicine · 2021Article
- Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.BMC endocrine disorders · 2020Article
- P-selectin blockade ameliorates lupus nephritis in MRL/lpr mice through improving renal hypoxia and evaluation using BOLD-MRI.Journal of translational medicine · 2020Article
- The Ser290Asn and Thr715Pro Polymorphisms of theBiomolecules · 2020Article
- Relationship Between -2028 C/T SELP Gene Polymorphism, Concentration of Plasma P-Selectin and Risk of Malnutrition in Head and Neck Cancer Patients.Pathology oncology research : POR · 2019Article
- Genetic polymorphisms of C-type lectin receptors in Behcet's disease in a Chinese Han population.Scientific reports · 2017Article
- P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus.Scientific reports · 2017Article
- Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population.Scientific reports · 2016Article
- The Relationship between P-Selectin Polymorphisms and Thrombosis in Antiphospholipid Syndrome: A Pilot Case-Control Study.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2014Article
- An antibody-based leukocyte-capture microarray for the diagnosis of systemic lupus erythematosus.PloS one · 2013Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Genome-wide linkage studies implicated a region containing the adhesion molecule P-Selectin. This family-based study revealed two regions of association within P-Selectin. The strongest signal, from a 21.4-kb risk haplotype, stretched from the promoter into the first two consensus repeat (CR) regions (P=8 x 10(-4)), with a second association from a 14.6-kb protective haplotype covering CR 2-9 (P=0.0198). The risk haplotype is tagged by the rare C allele of rs3753306, which disrupts the binding site of the trans-activating transcription factor HNF-1. One other variant (rs3917687) on the risk haplotype was significant after permutation (P(10000)<1 x 10(-5)), replicated in independent pseudo case-control analysis and was significant by meta-analysis (P=4.37 x 10(-6)). A third associated variant on the risk haplotype (rs3917657) replicated in 306 US SLE families and was significant in a joint UK-SLE data set after permutation. The protective haplotype is tagged by rs6133 (a non-synonymous variant in CR8 (P=9.00 x 10(-4)), which also shows association in the pseudo case-control analysis (P=1.09 x 10(-3)) and may contribute to another signal in P-Selectin. We propose that polymorphism in the upstream region may reduce expression of P-Selectin, the mechanism by which this promotes autoimmunity is unknown, although it may reduce the production of regulatory T cells.
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